Rob Dillard

DocwireNews

A study published in Kidney International Reports found heterogeneity with respect to kidney complications associated with chronic myelomonocytic leukemia (CMML) and BCR-ABL-negative myeloproliferative neoplasms (MPNs).In this case series, researchers assessed 18 patients with myeloid neoplasms (CMML, n=8; essential thrombocytosis [ET],&nbsp;n=7; polycythemia vera [PV], n=1; myelofibrosis,&nbsp;n=2) who were diagnosed with acute kidney injury (AKI), chronic kidney disease (CKD), or urine abnormalities. Thirteen of 18 patients were male.The results of the analysis showed that 12 patients had AKI at presentation, while eight patients had glomerular presentation. The results of kidney biopsy in 14 patients showed heterogeneity, including pauci-immune glomerulosclerosis (n=5), extramedullary hematopoiesis (n=6), or tubular atrophy and interstitial fibrosis with polymorphic inflammation (n=8).Subsequent to a follow-up of about two years, malignancy was considered stable in 61% of the study population, but 22% of patients had progressed to end-stage renal failure. The remaining patients had persistently reduced kidney function, the researchers noted. They did not observe a correlation between the malignancy and renal presentation and outcomes&ldquo;Kidney complications of CMML/MPN are heterogenous, and kidney biopsy may help to identify new molecular targets to prevent the development of kidney fibrosis,&rdquo; the researchers concluded.

BMI Modifies the Relationship Between Glycemic Status and Asthma Severity in Children

Asthma

Jordana Jampel

Cutaneous Melanoma: Sun Protection Behaviors and UV Exposure in Canada

Melanoma

Leah Lawrence

Significant Cardiac Benefit Seen With Ifetroban in Patients With Duchenne Muscular Dystrophy

Neurology

Latest News

Kidney Complications Are Heterogenous in CMML

A study published in Kidney International Reports found heterogeneity with respect to kidney complications associated with chronic myelomonocytic leukemia (CMML) and ...

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HER2 Breast Cancer

HR Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe