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Breast Cancers Today

Breast Cancers Today features breaking news, commentary, expert interviews, and more updates to inform healthcare professionals on the latest research and best clinical practices in the breast cancer space.

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Optimizing PARP Inhibitor Use in TNBC: Mechanisms, Combinations, and Clinical Strategies

Mark Robson, MD, of Memorial Sloan Kettering Cancer Center, explores the evolving role of PARP inhibitors in triple-negative breast cancer (TNBC), with a focus on their mechanisms of action, combination strategies, and clinical application. Dr. Robson addresses key challenges around sequencing with other therapies like ADCs and checkpoint inhibitors, shares insights from recent trials including OPERETTA, CompLEEment, and MEDIOLA, and highlights ongoing efforts to refine biomarkers and improve treatment personalization.

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