Kaitlyn D’Onofrio

DocwireNews

New research suggests that partial or total colectomy could&nbsp;put patients at a greater risk of&nbsp;type 2 diabetes.&nbsp;Researchers used the&nbsp;Danish National Patient Register&nbsp;to identify 46,279 total colectomy, partial colectomy, and proctectomy patients. Each colectomy patient was matched with 15 non-colectomy patients (n = 694,110) who had undergone other surgeries not related to the gastrointestinal tract. Mean follow-up times were as follows: total colectomy patients, 7.1 years; right hemicolectomy patients, 5.6 years; resection of the transverse colon patients,&nbsp;6.3 years; left hemicolectomy patients, 5.7 years;&nbsp;sigmoidectomy&nbsp;patients, 6.4 years; and proctectomy patients, 5.8 years.&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
A new study shows patients who undergo colectomy are at an increased risk of developing type 2 <a href="https://twitter.com/hashtag/diabetes?src=hash&amp;ref_src=twsrc%5Etfw">#diabetes</a>. <a href="https://twitter.com/bcmhouston?ref_src=twsrc%5Etfw">@bcmhouston</a>'s Dr. Rajesh Shah comments on the research. <a href="https://twitter.com/medpagetoday?ref_src=twsrc%5Etfw">@medpagetoday</a> <a href="https://t.co/nk62MFl8pr">https://t.co/nk62MFl8pr</a>
&mdash; BCM Media Relations (@BCMHouston_News) <a href="https://twitter.com/BCMHouston_News/status/1059462893723357184?ref_src=twsrc%5Etfw">November 5, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>Compared with non-colectomy patients, total colectomy patients (n = 3,793) were 1.4 times as likely to have type 2 diabetes (95% confidence interval [CI], 1.21 to 1.62;&nbsp;P&nbsp;&lt;&nbsp;0.001).&nbsp;Left hemicolectomy (n = 2,513) and&nbsp;sigmoidectomy&nbsp;(n = 13,927) patients had the highest hazard ratios (HRs) for type 2 diabetes: 1.41&nbsp;(95% CI, 1.19 to 1.67;&nbsp;P&nbsp;&lt;&nbsp;0.001) and 1.30 (95% CI, 1.21 to 1.40;&nbsp;P&nbsp;&lt;&nbsp;0.001), respectively.&nbsp;Right hemicolectomy (n = 10,989) and transverse colon resection patients (n = 673) did not have a significantly increased diabetes risk (right hemicolectomy HR, 1.08 [95% CI, 0.99 to 1.19;&nbsp;P&nbsp;= 0.10]; transverse colon resection HR, 1.08 [95% CI, 0.76 to 1.54;&nbsp;P&nbsp;=&nbsp;0.66]). Proctectomy patients (n = 14,384) did not have an increased risk of type 2 diabetes (HR, 0.98 [95% CI, 0.91 to 1.07;&nbsp;P&nbsp;=&nbsp;0.71]).&nbsp;The researchers called for future studies to evaluate the colon&rsquo;s role in glucose production.&nbsp;&ldquo;We know that the colon houses large numbers of gut bacteria and hormone-producing cells, but we still do not know which role they play in regulating the blood sugar level,&rdquo; said study co-author Kristine&nbsp;Allin, head of section and staff doctor at the Center for Clinical Research and Prevention at&nbsp;Bispebjerg&nbsp;and Frederiksberg Hospitals. &ldquo;We hope our study will facilitate further research into the significance of the colon in blood sugar regulation and diabetes development.&rdquo;&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Colectomy increases the risk of diabetes <a href="https://twitter.com/hashtag/sciencenews?src=hash&amp;ref_src=twsrc%5Etfw">#sciencenews</a> <a href="https://twitter.com/hashtag/diabetes?src=hash&amp;ref_src=twsrc%5Etfw">#diabetes</a> <a href="https://twitter.com/hashtag/colectomy?src=hash&amp;ref_src=twsrc%5Etfw">#colectomy</a> <a href="https://t.co/o4BN7nCo8D">https://t.co/o4BN7nCo8D</a> <a href="https://t.co/jHKXw767Du">pic.twitter.com/jHKXw767Du</a>
&mdash; ScienceBriefss (@ScienceBriefss) <a href="https://twitter.com/ScienceBriefss/status/1057999550974189569?ref_src=twsrc%5Etfw">November 1, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>One of the study&rsquo;s strengths is that it does not rely on animal testing, according to co-author&nbsp;S&oslash;ren&nbsp;Brunak&nbsp;of&nbsp;the Novo Nordisk Foundation Center for Protein Research.&nbsp;&ldquo;The surgical procedures these patients have undergone represent the&nbsp;&lsquo;trial,&rsquo;&nbsp;and the results are then determined from the many data held in the Danish registers,&rdquo; said professor&nbsp;Brunak. &ldquo;Researchers often use animal testing to identify a connection, before determining whether the results also apply to humans. Here we are looking directly at surgery on humans, and we do not have to worry about whether the findings also apply to humans. The human as a &lsquo;model organism&rsquo; is a concept that is gaining ground, ensuring that new patients benefit from experience and data collected through 20 years of treatment of previous patients.&rdquo;&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
The colon may play a role in regulating our blood sugar level, a new study suggest <a href="https://twitter.com/hashtag/science?src=hash&amp;ref_src=twsrc%5Etfw">#science</a> <a href="https://twitter.com/hashtag/health?src=hash&amp;ref_src=twsrc%5Etfw">#health</a> <a href="https://twitter.com/hashtag/diabetes?src=hash&amp;ref_src=twsrc%5Etfw">#diabetes</a> <a href="https://twitter.com/hashtag/dkvid?src=hash&amp;ref_src=twsrc%5Etfw">#dkvid</a> <a href="https://twitter.com/hashtag/dkforsk?src=hash&amp;ref_src=twsrc%5Etfw">#dkforsk</a> <a href="https://twitter.com/eLife?ref_src=twsrc%5Etfw">@eLife</a> @NNFCPR <a href="https://twitter.com/Metabolcenter?ref_src=twsrc%5Etfw">@Metabolcenter</a> <a href="https://t.co/7ObPkATtLg">https://t.co/7ObPkATtLg</a>
&mdash; UCPH Healthscience (@UCPH_health) <a href="https://twitter.com/UCPH_health/status/1057616675816775680?ref_src=twsrc%5Etfw">October 31, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>One of the study&rsquo;s limitations is that the authors did not control for all confounding factors, including medications. Another limitation is its reliance on the registry, which does not account patients with undiagnosed diabetes or who were diagnosed outside of the hospital.&nbsp;&ldquo;The greater majority of the body&rsquo;s microbes are found in the colon, so it is relevant to look at what happens after the colon or part of it is removed,&rdquo; said study co-author&nbsp;Thorkild&nbsp;I.A.&nbsp;S&oslash;rensen, a professor&nbsp;from the Department of Public Health and Novo Nordisk Foundation Center for Basic Metabolic Research.&nbsp;<a href="https://proddocwire.wpengine.com/hematology-oncology/ablative-stereotactic-radiotherapy-for-oligometastatic-colorectal-cancer-systematic-review/">Ablative stereotactic radiotherapy for oligometastatic colorectal cancer: Systematic review</a>&nbsp;<a href="https://proddocwire.wpengine.com/docwire-pick/diet-soda-reduces-colon-cancer/">Diet Soda Reduces Colon Cancer?</a>&nbsp;<a href="https://proddocwire.wpengine.com/uncategorized/brca-mutations-colorectal-cancer/">BRCA1 and BRCA2 Gene Mutations and Colorectal Cancer Risk: Systematic Review and Meta-analysis</a>&nbsp;<a href="https://proddocwire.wpengine.com/gastroenterology/does-the-site-of-primary-colorectal-cancer-influence-the-outcome-after-resection-of-isolated-liver-metastases/">Does the site of primary colorectal cancer influence the outcome after resection of isolated liver metastases?</a>&nbsp;Sources: <a href="https://healthsciences.ku.dk/news/2018/10/colectomy-associated-with-increased-risk-of-diabetes/">University of Copenhagen Faculty of Health and Medical Sciences</a>,&nbsp;<a href="https://elifesciences.org/articles/37420">eLIFE&nbsp;</a>

Jordana Jampel

Mechanism of Positive Association Between Parkinson’s Disease and Melanoma Revealed in New Research

Melanoma

Hatem Soliman, MD

Using Dendritic Cell Vaccines to Boost Neoadjuvant Therapy in HER2+ Breast Cancer

HER2 Breast Cancer

Kathleen Liu, MD

Joel M. Topf, MD, FACP

AKI Approaches and ASN Kidney Health Guidance

NKF Spring Clinical Meetings 2025

Latest News

Colectomy May Increase Type 2 Diabetes Risk

Diabetes

New research suggests that partial or total colectomy could put patients at a greater risk of type 2 diabetes.  ...