Research showed the historical effect of pneumococcal conjugate vaccines on infections in children with sickle cell disease. Maintenance with cetuximab monotherapy appeared to improve PFS and OS in patients with metastatic colorectal cancer. Early menopause, shortened reproductive span, and other reproductive factors were linked to risk of lung cancer in women. Patients with ibrutinib dose reduction after an AE had longer treatment length and similar efficacy versus no dose reduction. A study on patterns in patients with CLL found the RFC regimen appeared to be most effective for OS and response rates. Patients with chronic lymphocytic leukemia experience more anxiety when receiving intravenous versus oral treatments. Patients with CLL who relapsed after HSCT and then received venetoclax therapy achieved outcomes consistent with trial data. Dr. Annie Evans, senior director of research and development at Metabolon, Inc., about the science of metabolomics. A study found key tumor heterogeneities, including Ki-67 indices, might contribute to disease progression in GEP-NETs. Lu-177-dotatate in PRRT appeared to treat GEP-NETs, though prior internal radiation may impede responses or worsen survival. Symptom burden, gender, and social functioning were factors that increased suicidal spectrum behaviors in patients with ADHD. JK5G postbiotics may improve gut microbiota, QOL, and appetite in patients with advanced NSCLC on PD-1 inhibitor therapy. Excessive daytime sleepiness was linked to a higher risk of premature all-cause death in female patients with OSA. Survey data showed patients with idiopathic hypersomnia self-reported substantially impaired QoL and daily functioning. Researchers developed a faster calculation for hypoxic burden using desaturations that was comparable with manual scoring. CPAP did not yield a cardiovascular benefit in patients with CAD and OSA, regardless of excessive daytime sleepiness status. Poor bleeding rates seen despite flawed data across studies on congenital hemophilia A without inhibitors on FVIII treatment. Sacubitril/valsartan therapy improved outcomes compared with enalapril in heart failure with preserved ejection fraction. Abatacept improved outcomes for rheumatoid arthritis refractory to methotrexate or TNFi versus rituximab or tocilizumab. Elevated IGFs predicted poor outcomes in type 2 diabetes, and levels remained high after 3 years of canagliflozin treatment.