Rebecca Araujo

DocwireNews

The novel prostate-specific membrane antigen (PSMA) tracer 18F-PSMA-1007 for positron emission tomography/computer tomography (PET/CT) imaging applications showed strong diagnostic efficacy for high-risk prostate cancer.PSMA is a membrane-bound enzyme that is highly expressed in in prostate <a href="https://www.docwirenews.com/abstracts/hem-onc-abstracts/retooling-a-blood-based-biomarker-phase-i-assessment-of-the-high-affinity-ca19-9-antibody-humab-5b1-for-immuno-pet-imaging-of-pancreatic-cancer/">cancer</a> cells. Targeted imaging of PSMA has recently been adapted into clinical settings, as expression levels are associated with prostate cancer progression. PSMA-based PET/CT imaging has been reported to enable better tumor detection compared with standard radiologic imaging.This retrospective study assessed the clinical value of the novel tracer in diagnosing non-metastatic high-risk prostate cancer, enrolling 101 patients with primary non-metastatic disease who underwent imaging with 18F-PSMA-1007. Patients were divided into an Intermediate-risk (IR) group (n=49) or a high-risk (HR) group (n=52), according to European Association of Urology guidelines.Maximum standardized uptake levels (SUVmax) of the primary prostate tumor were measured via PET/CT images. Diagnostic performance of the images for each group was calculated, and the relationship between the SUVmax of the primary tumor, prostate-specific antigen (PSA) level, and Gleason prostate cancer staging score (GS) was analyzed.PSA level, GS, and SUVmax were significantly positively correlated (P &lt; 0.001). The median SUVmax in patients of HR was significantly higher than those of IR (16.85 vs 7.80, respectively; P&thinsp;&lt;&thinsp;0.001).The researchers found a positive correlation between the intensity of 18F-PSMA-1007 accumulation and the GS/PSA level in the primary prostate tumors. Tumors with GS 6 and 7a showed significantly lower 18F-PSMA-1007 uptake compared to tumors with GS 8 and 9 (P&thinsp;&lt;&thinsp;0.01).&ldquo;18F-PSMA-1007 was a great potential tracer for [prostate cancer (PCa)] PET/CT imaging,&rdquo; the researchers concluded. &ldquo;Furthermore, 18F-PSMA-1007 PET/CT showed powerful diagnostic performance for risk stratification of primary PCa, which can be used as a reference index for identifying high-risk PCa.&rdquo;The results of this <a href="https://ejnmmires.springeropen.com/articles/10.1186/s13550-020-00730-1">study</a> were published in EJNMMI Research.

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The novel prostate-specific membrane antigen (PSMA) tracer 18F-PSMA-1007 for positron emission tomography/computer tomography (PET/CT) imaging applications showed strong ...

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