Dr. Jeff Sharman discusses the nuances of CLL management and how to treat the disease using an algorithm. Dr. Fahar Merchant, president and CEO of Medicenna, talks about a promising therapy for combating recurrent glioblastoma. Patients with ibrutinib dose reduction after an AE had longer treatment length and similar efficacy versus no dose reduction. A study on patterns in patients with CLL found the RFC regimen appeared to be most effective for OS and response rates. Patients with chronic lymphocytic leukemia experience more anxiety when receiving intravenous versus oral treatments. Patients with CLL who relapsed after HSCT and then received venetoclax therapy achieved outcomes consistent with trial data. The group kicks off a new series on DLBCL, starting with the basics that come before disease management. Kaele Leonard, a pulmonary/critical care fellow who was diagnosed with breast cancer at a young age, discusses her journey. Dr. Urvi Shah sheds light on how dietary changes can modify the microbiome and prevent cancer. Researchers at the City of Hope developed a targeted chemotherapy that appears to destroy solid tumors. The Fellow on Call: The Heme/Onc Podcast covers HER2-positive breast cancer in part 11 of its series on breast cancer types. The Fellow on Call: The Heme/Onc Podcast switches from localized breast cancers to metastatic subtypes, starting with ER+. Dr. S. Vincent Rajkumar and The Oncology Brothers develop an algorithm for patients with MGUS or smoldering multiple myeloma. MRI-guided adaptive radiation led to reduced genitourinary toxicity in prostate cancer radiotherapy. Prostate-specific membrane antigen PET imaging predicted prostate cancer recurrence risk post-surgery, even before operation. A panel discussed the optimal treatment for patients with acute myeloid leukemia, as well as maintenance approaches. Options for treating ALL have improved in recent years, but questions about treatment approaches remain. There is no optimal initial therapy for patients with chronic lymphocytic leukemia, and multiple factors should be evaluated. Dr. Chadi Nabhan is joined by Dr. Ilana Yurkiewicz to discuss fragmentation within the health care system. Dr. Jens Hillengass joins The Oncology Brothers to discuss an algorithm for treating multiple myeloma.