Rob Dillard

DocwireNews

The human aging process may impede cancer development, according to the findings of a <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13041">recent study</a> published in Aging Cell.In this study, researchers utilized data from the Genotype&#8208;Tissue Expression (GTEx) Project and The Cancer Genome Atlas (TCGA) to compare genes differentially expressed with age and genes differentially expressed in cancer among nine human tissues.According to their findings, in most tissues, aging and cancer gene expression patterns changed in the opposite direction, suggesting that age hinders cancer progression. An exception was found in thyroid and uterus cancers, where researchers observed changes transcriptomic changes in the same direction, indicating cancer development with age. Moreover, the researchers observed that cellular senescence signatures changed directions as aging in human tissues aged and in the opposite direction of cancer signatures.&ldquo;One of the reasons our bodies have evolved to have senescent cells is to suppress cancers. But then it seems that senescent cells accumulate in aged human tissues and may contribute to ageing and degeneration,&rdquo; said Dr. Joao Pedro De Magalhaes from the University of Liverpool&rsquo;s Integrative Genomics and Ageing Group said in a <a href="https://www.eurekalert.org/pub_releases/2019-09/uol-sfa092719.php">press release</a>. &ldquo;Importantly, our work challenges the traditional view concerning the relationship between cancer and ageing and suggests that ageing processes may hinder cancer development.&rdquo;Dr. De Magalhaes, the study&rsquo;s lead researcher added that &ldquo;while mutations accumulate with age and are the main driver of cancer, ageing tissues may hinder cell proliferation and consequently cancer. So, you have these two opposite forces, mutations driving cancer and tissue degeneration hindering it. This may explain why at very advanced ages cancer incidence levels off and may even decline.&rdquo;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Study finds <a href="https://twitter.com/hashtag/age?src=hash&amp;ref_src=twsrc%5Etfw">#age</a> hinders <a href="https://twitter.com/hashtag/cancer?src=hash&amp;ref_src=twsrc%5Etfw">#cancer</a> development <a href="https://t.co/JWlcMyaGXT">https://t.co/JWlcMyaGXT</a>
&mdash; Medical Xpress (@medical_xpress) <a href="https://twitter.com/medical_xpress/status/1177601259613933570?ref_src=twsrc%5Etfw">September 27, 2019</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>&ldquo;Our results highlight the complex relationship between ageing, cancer and cellular senescence and suggest that in most human tissues ageing processes and senescence act in tandem while being detrimental to cancer,&rdquo; Dr. De Magalhaes concluded. &ldquo;But more mechanistic studies are now needed.&rdquo;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Study finds age hinders cancer development 
Researchers believe the changes in aging and cellular senescence might relate to a decrease in cell proliferation, while cancer changes shift towards an increase in cell division.<a href="https://t.co/yy4Azkt3gs">https://t.co/yy4Azkt3gs</a>
&mdash; Neuroscience News (@NeuroscienceNew) <a href="https://twitter.com/NeuroscienceNew/status/1177668326002221056?ref_src=twsrc%5Etfw">September 27, 2019</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Study finds age hinders cancer development <a href="https://t.co/SMMp6LBD2n">https://t.co/SMMp6LBD2n</a> <a href="https://t.co/KmkQP1C0KJ">pic.twitter.com/KmkQP1C0KJ</a>
&mdash; Ward Plunet (@WardPlunet) <a href="https://twitter.com/WardPlunet/status/1177755814284660737?ref_src=twsrc%5Etfw">September 28, 2019</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>&nbsp;&nbsp;

Bradley Warady, MD

Joel M. Topf, MD, FACP

2025 Hume Award Winner Is Dedicated to Children’s Care

NKF Spring Clinical Meetings 2025

Jordana Jampel

Distant Brain Metastases in Cutaneous Melanoma May Be Mitigated With Multiple Pathway Inhibitors

Melanoma

Eric Bergson, MD

The Role of Multidisciplinary Care in Head and Neck Cancer

Head and Neck Cancer

Latest News

Age Inhibits Cancer Development

Oncology

The human aging process may impede cancer development, according to the findings of a recent study published in Aging Cell. ...

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HER2 Breast Cancer

HR Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Skin Cancer

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe