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Leah Lawrence
Leah Lawrence
Articles by Leah Lawrence
Changing the Conversation: Obesity as Chronic Disease
Leah Lawrence
Metabolic Disorders
|
May 22, 2025
Obesity is a chronic, complex disease driven by biology, not just behavior—effective care requires empathy and support.
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Innate Immunity Has a Role in Vitiligo Pathogenesis
Leah Lawrence
Dermatology
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May 20, 2025
TLR9 gene variants may influence vitiligo risk, new research suggests innate immunity plays a key role.
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Bilirubin May Have Protective Role Against Vitiligo
Leah Lawrence
Dermatology
|
May 20, 2025
Elevated bilirubin levels may lower vitiligo risk, suggesting a protective role, new genetic study finds.
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JAK Inhibitor Significantly Improved Hair Regrowth for Severe Alopecia
Leah Lawrence
Dermatology
|
May 20, 2025
Tofacitinib shows promising 6-month results for alopecia totalis and universalis, with notable hair regrowth and safety profi
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Role of JAK Inhibitors for Vitiligo Remains Unclear
Leah Lawrence
Dermatology
|
May 20, 2025
Topical JAK inhibitors show promise for vitiligo, but current evidence lacks strong statistical support, study finds.
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Significant Cardiac Benefit Seen With Ifetroban in Patients With Duchenne Muscular Dystrophy
Leah Lawrence
Neurology
|
May 12, 2025
Ifetroban shows significant 12-month cardiac benefit in DMD patients, per phase-2 FIGHT DMD trial results.
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Apitegromab Improved Motor Function in Type 2/3 Spinal Muscular Atrophy
Leah Lawrence
Neurology
|
May 12, 2025
Apitegromab improves motor function in SMA patients aged 2–21, per phase-3 SAPPHIRE trial results.
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Losmapimod Did Not Benefit Patients with Facioscapulohumeral Muscular Dystrophy
Leah Lawrence
Neurology
|
May 12, 2025
Losmapimod failed to show clinical benefit over placebo in FSHD patients in the phase 3 REACH trial, ending its development.
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Gene Therapy Breakthrough: One-Time Intrathecal Treatment Significantly Boosts Motor Function in Older SMA Patients, STEER Trial Finds
Leah Lawrence
Neurology
|
May 12, 2025
Intrathecal gene therapy OA significantly improved motor function in older SMA patients in phase-3 STEER trial.
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Real-World Data Backs Invasive DFS as Surrogate Endpoint for OS in EBC
Leah Lawrence
HR Breast Cancer
|
April 17, 2025
iDFS strongly correlates with OS in HR+/HER2- early breast cancer, supporting its use as a surrogate endpoint in trials.
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Sacituzimab Govitecan Showed Modest Activity for CNS Metastases
Leah Lawrence
Triple-Negative Breast Cancer
|
April 15, 2025
Sacituzimab govitecan showed modest CNS activity in pretreated HER2-negative metastatic breast cancer with brain metastases.
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De-Escalation of Neoadjuvant Chemoimmunotherapy May Be Feasible Option
Leah Lawrence
Triple-Negative Breast Cancer
|
April 9, 2025
Shorter chemoimmunotherapy shows promise in early TNBC, with higher pCR in PD-L1+ or TIL-high patients, Neo-N trial finds.
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Imlunestrant is a Viable Second-Line Option for Advanced HR-Positive, HER2-Negative Breast Cancer
Leah Lawrence
HR Breast Cancer
|
April 7, 2025
Imlunestrant with or without abemaciclib improved PFS in ER+/HER2- advanced breast cancer post-endocrine therapy.
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Trastuzumab Deruxtecan Approved for HER2-Low, Ultralow Metastatic Breast Cancer
Leah Lawrence
HER2 Breast Cancer
|
March 31, 2025
The FDA approved trastuzumab deruxtecan for HR-positive/HER2-low metastatic breast cancer based on DESTINY-Breast06 results.
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ADC Emi-Le Fast Tracked for HER2-Low/Negative Breast Cancer
Leah Lawrence
HER2 Breast Cancer
|
March 31, 2025
The FDA granted Fast Track status to emiltatug ledadotin for advanced breast cancer following phase 1 results targeting B7-H4
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CheckMate 77T Analysis Evaluates Perioperative Nivolumab in Resectable NSCLC
Leah Lawrence
ASCO 2024: Focus on Lung Cancer
|
July 10, 2024
Researchers compared outcomes between patients with baseline stage III N2 and non-N2 NSCLC.
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Is Neoadjuvant Nivolumab Plus Chemotherapy Feasible for Resectable Diffuse Pleural Mesotheliomas?
Leah Lawrence
ASCO 2024: Focus on Lung Cancer
|
July 3, 2024
A pilot study evaluated neoadjuvant platinum, pemetrexed, and nivolumab followed by pleurectomy/decortication.
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DeLLphi-301 Analysis: Tarlatamab Is Active in SCLC, Regardless of Baseline Brain Metastases
Leah Lawrence
ASCO 2024: Focus on Lung Cancer
|
July 2, 2024
Study investigators say the results support further study of the bispecific T-cell engager in previously treated SCLC.
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KEYNOTE-671 Trial Evaluates Quality of Life With Perioperative Pembrolizumab for Early Stage, Resectable NSCLC
Leah Lawrence
ASCO 2024: Focus on Lung Cancer
|
June 24, 2024
An analysis of the phase 3 trial evaluated multiple aspects of health-related quality of life.
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KRYSTAL-12: Adagrasib Significantly Improved PFS, Response in Certain Form of NSCLC
Leah Lawrence
ASCO 2024: Focus on Lung Cancer
|
June 18, 2024
The study "confirmed the role of adagrasib compared to docetaxel" in terms of PFS, response rate, and intracranial response.
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