Kaitlyn D’Onofrio

DocwireNews

A study published in <a href="https://onlinelibrary.wiley.com/doi/10.1002/cam4.3882">Cancer Medicine</a> found that surgery may be a beneficial treatment option for certain patients with primary intestinal diffuse large B-cell lymphoma (PI-DLBCL).The Surveillance, Epidemiology, and End Results program was queried to collect data on adult patients with PI-DLBCL. The researchers used Kaplan-Meier and Cox proportional regression analyses to determine the impact of surgical treatment. Lasso regression was implemented to identify factors associated with overall survival (OS) for a nomogram and a novel web&#8208;based calculator. Concordance index, receiver operating characteristic curve, and calibration were used to evaluate the model&rsquo;s performance.Final analysis included 1,602 patients with PI-DLBCL. Surgery was associated with significantly improved survival upon univariate (P=0.007) and multivariate analyses (P&lt;0.002). For patients who did not receive chemotherapy, local tumor destruction (LTD), compared to resection, was associated with better survival before propensity score matching was implemented. But upon matching, surgery remained associated with improved OS (P=0.0015), while LTD and resection no longer largely differed (P=0.32). Three-, five-, and 10-year predictions of OS per the nomogram were consistent between internal and external validation sets, according to the researchers.&ldquo;This study approves the beneficial effect of surgery on clinical endpoints in PI&#8208;DLBCL patients. For those who are not suitable for resection, LTD may also be a practical option,&rdquo; the authors wrote in their conclusion. &ldquo;The predictive nomogram and the web&#8208;based calculator could help clinicians individually evaluate the prognosis and optimize personalized treatment decisions for these patients.&rdquo;

Jordana Jampel

Mechanism of Positive Association Between Parkinson’s Disease and Melanoma Revealed in New Research

Melanoma

Hatem Soliman, MD

Using Dendritic Cell Vaccines to Boost Neoadjuvant Therapy in HER2+ Breast Cancer

HER2 Breast Cancer

Kathleen Liu, MD

Joel M. Topf, MD, FACP

AKI Approaches and ASN Kidney Health Guidance

NKF Spring Clinical Meetings 2025

Latest News

Surgery a Beneficial Option for Primary Intestinal DLBCL

Oncology

A study published in Cancer Medicine found that surgery may be a beneficial treatment option for certain patients with primary intestinal diffuse large B-cell lymphoma ...

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HR Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe