Kerri Fitzgerald

DocwireNews

A recent study published in JAMA corroborated a <a href="https://www.docwirenews.com/docwire-pick/hem-onc-picks/fda-sunscreen-absorbed-bloodstream/">statement from the U.S. Food and Drug Administration</a> (FDA) last year that found active ingredients in sunscreen can be absorbed into the bloodstream. This recent study replicated a pilot trial conducted in 2018 and reported on by the FDA in May 2019. The FDA has proposed a rule requiring sunscreen manufacturers to provide additional information on the active ingredients in their products.The randomized clinical trial took place at a clinical pharmacology unit in West Bend, Wisconsin and included 48 healthy participants (mean age, 38.7 years; 50% were women; 48% were white) between January 2019 and February 2019. Participants were randomized to one of four sunscreen products: lotion (n=12), aerosol spray (n=&thinsp;12), non-aerosol spray (n=12), and pump spray (n=12).Sunscreen was applied at 2 mg/cm2&nbsp;to 75% of body surface area at zero hours on day one and four times on days two through four at two-hour intervals. A total of 34 blood samples were collected over 21 days from each participant.Researchers assessed maximum plasma concentrations for six active ingredients in sunscreen: avobenzone, oxybenzone, octocrylene, homosalate, octisalate, and octinoxate. The FDA recommends exposure of these ingredients not exceed 0.5 ng/mL.<h2>All ingredients exceeded maximum recommendations from FDA</h2>Geometric mean <a href="https://www.docwirenews.com/latest-general-medical-news/effect-of-sunscreen-application-under-maximal-use-conditions-on-plasma-concentration-of-sunscreen-active-ingredients-a-randomized-clinical-trial/">maximum plasma concentrations</a> of all six active ingredients were greater than 0.5 ng/mL, and this threshold was surpassed after a single application for all active ingredients.For avobenzone (primary outcome), the overall maximum plasma concentrations were 7.1 ng/mL for lotion, 3.5 ng/mL for aerosol spray, 3.5 ng/mL for non-aerosol spray, and 3.3 ng/mL for pump spray.For oxybenzone, the concentrations were 258.1 ng/mL for lotion and 180.1 ng/mL for aerosol spray. For octocrylene, the concentrations were 7.8 ng/mL for lotion, 6.6 ng/mL for aerosol spray, and 6.6 ng/mL for non-aerosol spray. For homosalate, concentrations were 23.1 ng/mL for aerosol spray, 17.9 ng/mL for non-aerosol spray, and 13.9 ng/mL for pump spray. For octisalate, concentrations were 5.1 ng/mL for aerosol spray, 5.8 ng/mL for non-aerosol spray, and 4.6 ng/mL for pump spray. For octinoxate, concentrations were 7.9 ng/mL for non-aerosol spray and 5.2 ng/mL for pump spray.The most common adverse event was rash (n=14).Despite the findings, the researchers cautioned, &ldquo;These findings do not indicate that individuals should refrain from the use of sunscreen.&rdquo;

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New Study Confirms Previous FDA Statement That Active Ingredients in Sunscreen Are Absorbed into the Bloodstream

Oncology

A recent study published in JAMA corroborated a statement from the U.S. Food and Drug Administration (FDA) last year that found active ingredients in sunscreen can be absorbed ...

New Study Confirms Previous FDA Statement That Active Ingredients in Sunscreen Are Absorbed into the

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