Patrick Daly

DocwireNews

According to a study published in the&nbsp;Journal of Clinical Oncology, older survivors of breast cancer have a higher risk for clinical decline after undergoing adjuvant <a href="https://medlineplus.gov/ency/article/002324.htm">chemotherapy</a>. The study&rsquo;s authors investigated if inflammatory markers prior to adjuvant therapy were associated with clinical declines in frailty status.They found that high interleukin (IL)-6 and C-reactive protein (CRP) levels were associated with a chemotherapy-induced decline in frailty status. The authors noted that this decline was independent of sociodemographic characteristics and other clinical risk factors.This prospective study included a total of 295 women aged 65 years or more with stage 1 to 3 breast cancer treated with chemotherapy. Both pre- and post-chemotherapy, researchers evaluated the participants for IL-6 and CRP levels, as well as frailty status based on a deficit accumulation index (DAI; robust, prefrail, or frail). All patients were categorized as robust prior to chemotherapy.<h3>IL-6 and CRP Predict Clinical Decline After Adjuvant Chemotherapy for Breast Cancer</h3>The authors reported that 76 (26%) of patients had chemotherapy-induced declines in frailty status, of which 66% had high IL-6, 63% had high CRP, and 46% had both prior to chemotherapy. Based on multivariate logistic regression adjusting for sociodemographic and clinical characteristics, high IL-6 and CRP levels were associated with a more than three-fold increased risk for decline in frailty status compared to patients with low IL-6 and CRP (odds ratio, 3.52; 95% CI, 1.55-8.01; P=.003).&ldquo;In this cohort of older women with early breast cancer who were clinically fit before chemotherapy initiation,&rdquo; the authors summarized, &ldquo;high IL-6 and CRP prechemotherapy were associated with chemotherapy-induced decline in frailty status independent of sociodemographic and clinical risk factors&rdquo;They added that future research is warranted to determine whether inflammatory biomarkers could inform more personalized treatment plans for older survivors of breast cancer.Read More <a href="https://www.docwirenews.com/breast-cancer-resource-center/">Recent Articles and Interviews on Breast Cancer</a>

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According to a study published in the Journal of Clinical Oncology, older survivors of breast cancer have a higher risk for clinical decline after undergoing adjuvant ...

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