Kerri Fitzgerald

DocwireNews

A study presented at the Transplantation &amp; Cellular Therapy Meetings found that non-invasive candidiasis and opportunistic viral infections are common adverse events of chimeric antigen receptor <a href="https://www.docwirenews.com/docwire-pick/hem-onc-picks/car-t-cell-therapy-induces-response-in-nhl-and-cll/">(CAR) T-cell</a> therapy that &ldquo;require more robust investigation and further evidence-based and consensus driven guidelines.&rdquo;This retrospective, single-center study included 38 patients (age range, 30-74 years; 68.4% were male)&nbsp;with relapsed/refractory non-Hodgkin lymphoma who received axicabtagene ciloleucel between January 2018 and October 2019.Infectious complications were identified and classified as bacterial, viral, and either non-invasive fungal or invasive fungal.<h2>Infections common following CAR T-cell therapy</h2>Following CAR-T treatment, most patients (79%; n=30) had viral (n=8; 21%), bacterial (n=16; 42%), or fungal infections (n=17; 45%). A total of 79% (n=30) experienced an episode of febrile neutropenia, and 22 of the 46 identified infections occurred during an episode of neutropenia.The most common sites of bacterial infections included blood stream infections (37.5%) and pulmonary (25.0%) sources.&nbsp;The most common viral infections identified were cytomegalovirus (36%), BK virus (18%), and respiratory syncytial&nbsp;virus (18%). The majority of the fungal infections were oral candidiasis (89.5%). Two patients developed an invasive mold infection.&ldquo;Overall, we had notable infectious findings including a high incidence of non-invasive candidiasis and occurrences of opportunistic viral infections associated with <a href="https://www.docwirenews.com/docwire-pick/hem-onc-picks/long-term-survival-observed-with-car-t-cell-therapy-for-b-cell-lymphoma/">CAR-T cell</a> therapy and lymphodepletion as compared to the literature,&rdquo; the authors concluded.

Bradley Marder, MD

Joel M. Topf, MD, FACP

Gout Studies: Transplant Waitlisting and Bone Erosion

NKF Spring Clinical Meetings 2025

Jayme Locke, MD, MPH

The Promise of Xenotransplantation

Leah Lawrence

Real-World Data Backs Invasive DFS as Surrogate Endpoint for OS in EBC

HR Breast Cancer

Latest News

Infectious Complications are Common After CAR T-Cell Therapy for NHL

Oncology

A study presented at the Transplantation &amp; Cellular Therapy Meetings found that non-invasive candidiasis and opportunistic viral infections are common adverse events of ...

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HER2 Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe