Kaitlyn D’Onofrio

DocwireNews

In a recent multi-center trial, researchers found that <a href="https://proddocwire.wpengine.com/conference-coverage/american-heart-association-2018-scientific-sessions/video-should-your-patients-keep-taking-fish-oil-and-vitamin-d-supplements/">fish oil</a> supplements have no impact on <a href="https://proddocwire.wpengine.com/conference-coverage/guidance-for-identifying-severe-asthma/">uncontrolled asthma</a> in overweight adolescent patients.A total of 98 patients aged between 12 and 25 years were randomized to receive a daily 4 g omega-3 fatty acid supplement (n = 77) or a protein-free soy oil placebo (n = 21) for 24 weeks. Eligible patients had physician-diagnosed asthma, uncontrolled asthma with the use of a daily inhaled corticosteroid controller, and overweight/obesity. The primary outcome was results from the Asthma Control Questionnaire (ACQ), and secondary outcomes were blood leukocyte n3PUFA levels, urinary leukotriene-E4 (uLTE4), spirometry, and asthma-related events.<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
No evidence that fish oil supplementation affects asthma in overweight patients in <a href="https://twitter.com/hashtag/RCT?src=hash&amp;ref_src=twsrc%5Etfw">#RCT</a>. Should I file this to Archives of RCTs disproving hypotheses generated from retrospective studies, or to the archives of inconclusive studies? <a href="https://twitter.com/hashtag/MondayMood?src=hash&amp;ref_src=twsrc%5Etfw">#MondayMood</a> <a href="https://twitter.com/hashtag/Asthma?src=hash&amp;ref_src=twsrc%5Etfw">#Asthma</a> <a href="https://t.co/Sh3hftgxkr">https://t.co/Sh3hftgxkr</a> <a href="https://t.co/7scinoRD6A">pic.twitter.com/7scinoRD6A</a>
&mdash; Naftali Kaminski (@KaminskiMed) <a href="https://twitter.com/KaminskiMed/status/1089906670757654528?ref_src=twsrc%5Etfw">January 28, 2019</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>More than 86% of patients completed the trial. The fish oil group had no change in mean ACQ at six months (fish oil group: -0.09 [-0.09, 0.10] vs. control group: -0.18 [-0.42, 0.06], p=0.58). Six-month changes were similar between both cohorts in uLTE (p=0.24), FEV1 percent predicted (p=0.88), and exacerbations (RR=0.92, 95% CI 0.30-2.89). One difference researchers noted, though, is that the fish oil group made fewer asthma-related phone calls to their providers (RR=0.34, 95% CI 0.13-0.86, p=0.02).<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
&ldquo;Fish Oil Flops for <a href="https://twitter.com/hashtag/Asthma?src=hash&amp;ref_src=twsrc%5Etfw">#Asthma</a> Control in Overweight Youth. No benefit versus soybean oil in exacerbations or lung function&rdquo; <a href="https://t.co/EDr9pBiw1C">https://t.co/EDr9pBiw1C</a> <a href="https://t.co/lE4cPBWSB3">pic.twitter.com/lE4cPBWSB3</a>
&mdash; Juan C Ivancevich MD (@Aller_MD) <a href="https://twitter.com/Aller_MD/status/1089161101856727040?ref_src=twsrc%5Etfw">January 26, 2019</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>&ldquo;That could be a red herring or it may mean something else,&rdquo; study author Jason E. Lang, MD, of Duke University, told <a href="https://www.medpagetoday.com/allergyimmunology/asthma/77628">MedPage Today</a>.The researchers chose this population because young age and overweight are risk factors for uncontrolled asthma, Lang said.&ldquo;We know that obesity is associated with more general inflammation,&rdquo; he said, adding, &ldquo;We don&rsquo;t really know why obesity is associated with worse asthma control, but it has been suggested that greater circulating inflammation would prime the lung and airways to be more hyperactive.&rdquo;https://twitter.com/sucharitakher/status/1090057145972916231In their report, the study authors concluded, &ldquo;In adolescents and young adults with overweight/obesity and uncontrolled asthma, fish oil supplementation at 4g/day increased n3PUFA concentration in peripheral blood monocytes and granulocytes. However, these enhancements did not translate to a measurable reduction in LTE4 production, asthma control, nor most secondary outcomes. These findings do not support a strategy of therapeutic n3PUFA supplementation in these patients with symptomatic asthma.&rdquo;<a href="https://proddocwire.wpengine.com/conference-coverage/american-heart-association-2018-scientific-sessions/video-should-your-patients-keep-taking-fish-oil-and-vitamin-d-supplements/">Should Your Patients Keep Taking Fish Oil And Vitamin D Supplements?</a><a href="https://proddocwire.wpengine.com/conference-coverage/guidance-for-identifying-severe-asthma/">Guidance for Identifying Severe Asthma</a><a href="https://proddocwire.wpengine.com/conference-coverage/asthma-copd-overlap-what-is-known-and-what-is-not/">Asthma-COPD Overlap: What Is Known and What Is Not</a><a href="https://proddocwire.wpengine.com/docwire-pick/home-page-picks/study-finds-fish-oil-pills-dont-benefit-heart-health/">Fish Oil Pills Have Little to No Effect on Cardiovascular Health</a>Source: <a href="http://www.thoracic.org/about/newsroom/press-releases/resources/fish-oil-and-asthma1.pdf">Annals of the American Thoracic Society</a>

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Fish Oil Does Not Help Uncontrolled Asthma

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In a recent multi-center trial, researchers found that fish oil supplements have no impact on uncontrolled asthma in overweight adolescent patients. ...

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