Kerri Fitzgerald

DocwireNews

A study published in&nbsp;the&nbsp;European Journal of Cancer&nbsp;found that anticoagulant use was not associated with improved overall survival (OS) in patients with glioblastoma.&nbsp;&nbsp;Researchers&nbsp;assessed survival associations of anticoagulant use from baseline&nbsp;to the start of temozolomide chemoradiotherapy (TMZ;&nbsp;period I) and from there to the start of maintenance TMZ chemotherapy (period II).&nbsp;&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Anticoagulants, also known as blood thinners, are often prescribed for a wide variety of conditions. Dr. Timothy Cloughesy recently contributed to a study that investigated if they had a role in treating glioblastomas. Read more: <a href="https://t.co/h1a3d3GljV">https://t.co/h1a3d3GljV</a> <a href="https://twitter.com/OncologyAdvance?ref_src=twsrc%5Etfw">@OncologyAdvance</a>
&mdash; UCLA Neurology (@UCLANeurology) <a href="https://twitter.com/UCLANeurology/status/1025994976486780929?ref_src=twsrc%5Etfw">August 5, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>They used data from 3&nbsp;randomized, clinical trials of 1,273 patients with&nbsp;newly diagnosed glioblastoma.&nbsp;Seventy-five patients (5.9%) used anticoagulants during period I and 104 patients (10.2%) used them during period II.&nbsp;Anticoagulant use during period II, was associated with inferior OS&nbsp;compared to no use&nbsp;(hazard ratio [HR] = 1.52;&nbsp;95%&nbsp;CI,&nbsp;1.18-1.95;&nbsp;P=0.001).&nbsp;However, there did not appear to be an association with survival when anticoagulants were used during period I.&nbsp;The researchers&nbsp;observed no decrease in OS when only patients with prophylactic anticoagulant use were considered.&nbsp;Antiplatelet agent use&nbsp;was also not associated with survival.&nbsp;<a href="https://proddocwire.wpengine.com/hematology-oncology/the-association-between-common-clinical-characteristics-and-postoperative-morbidity-and-overall-survival-in-patients-with-glioblastoma/">What is the association between common clinical characteristics and postoperative morbidity and overall survival in patients with glioblastoma?</a>&nbsp;Source:&nbsp;<a href="https://www.ejcancer.com/article/S0959-8049(18)30943-2/fulltext">European Journal of Cancer&nbsp;</a>

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Blood Thinners Not Associated With Improved Survival in Glioblastoma

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A study published in the European Journal of Cancer found that anticoagulant use was not associated with improved overall survival (OS) in patients with glioblastoma.   ...

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