Cynthia Miller, MD, MPH, FACP, discusses why early Lp(a) screening may help prevent cardiovascular disease. Women may garner the health benefits of regular exercise more than men. Semaglutide, used to treat diabetes and obesity, does not increase the risk of suicidal ideation, despite previous reports. Dr. Eugenia Alleva discusses a study that found women with dysmenorrhea have increased cardiovascular risk. Dr. Benjamin Horne discusses a study that showed increases in PM2.5 during the summer and winter impact heart health. Dr. Ijeoma Eleazu talks about the harmful impact of cumulative stress on cardiovascular health. CardioNerds correspondent Dr. Ahmed Ghoneem details the positive effects of semaglutide, as demonstrated in the SELECT trial. Dr. Karthik Gonuguntla discusses the study he led on cardiovascular health disparities in American Indian adults. Semaglutide reduced major CVD risk by 20% in adults with overweight or obesity, but not diabetes. Elevated lipoprotein(a) increases the risk of major adverse cardiovascular events independent of ASCVD risk scores. Cardiovascular deaths from extreme heat may more than double by the middle of the current century. Dr. Nathaniel Hawkins discusses the EXACOS-CV study, which uncovered an increased CV risk following COPD exacerbations. A fast-acting medication delivered as a nasal spray allows patients with intermittent rapid heartbeats to treat themselves. The CardioNerds correspondents Drs. Amo-Tweneboah and Nedadur preview the CLE Care of Aortic Disease Symposium. A research team highlighted three important debates on women’s cardiometabolic health. Dr. Tammy Polonsky discussed studies that have found a novel way to utilize an incidental finding seen on mammograms. Feeling safe from crime is linked to a lower risk of premature death and heart attack. Middle-aged adults with metabolic syndrome have heart attacks and strokes 2 years earlier than their peers. A study showed that physical fitness is associated with a lower likelihood of AFib and stroke. Children who are sedentary for hours per day may have a higher risk for heart attacks and strokes later in life.