Zaina Inam, MD

Leah Sherwood

Melissa Badamo

DocwireNews

Dr. Inam, of Children&rsquo;s National Hospital, joined Heme Today to discuss her study, &ldquo;Impact of Pre-HSCT RBC Alloimmunization on Post-HSCT Outcomes in Pediatric Patients With SCD,&rdquo; presented at the 2024 American Society of Pediatric Hematology/Oncology Conference.The retrospective, cohort study evaluated transplant outcomes in pediatric patients with sickle cell disease (SCD) who had a history of red blood cell alloimmunization versus those who did not have a history of alloimmunization.&ldquo;Our specific focus was looking at post-transplant transfusion for both red cells and platelets,&rdquo; Dr. Inam said. &ldquo;We also wanted to look at transplant outcomes such as graft failure, high-grade acute [graft-versus-host disease (GVHD)], and chronic GVHD.&rdquo;Dr. Inam and colleagues found that high-grade acute GVHD was significant in those who were alloimmunized compared with those who were not.&ldquo;It was a little surprising to us because we thought maybe we would see higher transfusion post-transplant,&rdquo; Dr. Inam said.Dr. Inam and colleagues only analyzed matched related donor transplant, but she hopes to study alternative donor transplant next to see if there are similar incidents of high-grade acute GVHD with those who are alloimmunized versus those who are not.

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Zaina Inam, MD, on Transplant Outcomes in Pediatric Patients With SCD

Sickle Cell Disease

The study evaluated transplant outcomes in pediatric patients with SCD who had a history of red blood cell alloimmunization.

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