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Extensive studies throughout the past 50 years&nbsp;have helped enable the prediction, as well as the reliable optimization, of the&nbsp;transport of a wide variety of molecules into cartilage.&nbsp;Continuing&nbsp;to develop these therapeutic molecules that&nbsp;target chondrocytes and locally produced inflammatory factors within arthritic cartilage&nbsp;has been a focus in study and investigation for some time.&nbsp;In this study by Nature Reviews Rheumatology,&nbsp;transport kinetics of therapeutics are summarized,&nbsp;and the factors are discussed.&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
<a href="https://twitter.com/hashtag/TrendingNow?src=hash&amp;ref_src=twsrc%5Etfw">#TrendingNow</a>: Molecular transport in articular cartilage &mdash; what have we learned from the past 50 years? Check it out for <a href="https://twitter.com/hashtag/free?src=hash&amp;ref_src=twsrc%5Etfw">#free</a> at <a href="https://t.co/4ACjzz7hOc">https://t.co/4ACjzz7hOc</a> <a href="https://twitter.com/hashtag/SharedIt?src=hash&amp;ref_src=twsrc%5Etfw">#SharedIt</a> <a href="https://twitter.com/hashtag/cartilage?src=hash&amp;ref_src=twsrc%5Etfw">#cartilage</a> <a href="https://twitter.com/hashtag/drugdevelopment?src=hash&amp;ref_src=twsrc%5Etfw">#drugdevelopment</a> <a href="https://twitter.com/hashtag/therapy?src=hash&amp;ref_src=twsrc%5Etfw">#therapy</a> <a href="https://t.co/YpCsUyAzq4">pic.twitter.com/YpCsUyAzq4</a>
&mdash; NatRevRheumatol (@NatRevRheumatol) <a href="https://twitter.com/NatRevRheumatol/status/1014267683565600769?ref_src=twsrc%5Etfw">July 3, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>According to the review, the&nbsp;most crucial factor when designing new therapeutic molecules is solute size, and the diffusivity and partition coefficient of a solute both decrease with increasing solute size.&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Article ( <a href="https://twitter.com/CornellBME?ref_src=twsrc%5Etfw">@CornellBME</a> <a href="https://twitter.com/BonassarLab?ref_src=twsrc%5Etfw">@BonassarLab</a> in <a href="https://twitter.com/NatRevRheumatol?ref_src=twsrc%5Etfw">@NatRevRheumatol</a> ): "Molecular transport in articular cartilage &mdash; what have we learned from the past 50 years?" <a href="https://t.co/9oL3VKlsnh">https://t.co/9oL3VKlsnh</a> <a href="https://t.co/sEu0HZN4hJ">pic.twitter.com/sEu0HZN4hJ</a>
&mdash; Cornell BME (@CornellBME) <a href="https://twitter.com/CornellBME/status/1014236470637416455?ref_src=twsrc%5Etfw">July 3, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Recently published review on molecular transport in articular cartilage <a href="https://t.co/STcXhqKhWh">https://t.co/STcXhqKhWh</a> &hellip; <a href="https://twitter.com/NatRevRheumatol?ref_src=twsrc%5Etfw">@NatRevRheumatol</a> has cited our paper <a href="https://twitter.com/BiophysJ?ref_src=twsrc%5Etfw">@BiophysJ</a> <a href="https://twitter.com/CellCellPress?ref_src=twsrc%5Etfw">@CellCellPress</a> <a href="https://t.co/MmGxOmP0fq">https://t.co/MmGxOmP0fq</a> &hellip; <a href="https://t.co/RjLJ0ouMVb">https://t.co/RjLJ0ouMVb</a> <a href="https://t.co/2jV5axTPsB">pic.twitter.com/2jV5axTPsB</a>
&mdash; Niloufar Khosr&agrave;vi (@NilKoh) <a href="https://twitter.com/NilKoh/status/1011258668162142209?ref_src=twsrc%5Etfw">June 25, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>By learning how to alterate&nbsp;the shape or charge of a solute, as well as&nbsp;the&nbsp;application of physiological loading to cartilage, this data can be used to better understand how to improve therapeutic agents for&nbsp;osteoarthritis that target the cartilage.&nbsp;SOURCE:&nbsp;<a href="https://www.nature.com/articles/s41584-018-0033-5.epdf?shared_access_token=oBwJCAgGU3p_i605aXeJ0tRgN0jAjWel9jnR3ZoTv0PFv1qmAAiGRK8_weNsHqnhjb75f5H3G7VTiT7eFsyGw9FetZ-fBT2zlBG57vXEMZhaqLCJWQWgp_nh9Ur1VC_DysfPtUd73ipLHRBfgNOcEI9M_iY36lz7u74rB8VM62s%3D">Nature Reviews Rheumatology&nbsp;</a>

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What Has the Past 50 Years Taught Us About Molecular Transport in Articular Cartilage?

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Extensive studies throughout the past 50 years have helped enable the prediction, as well as the reliable optimization, of the transport of a wide variety of molecules into ...