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Vitamin D is important to the health and wellness of&nbsp;one&rsquo;s body.&nbsp;In order to&nbsp;absorb calcium and promote bone growth, one must have vitamin D. It also aids in the development of teeth and can even&nbsp;improve resistance against certain diseases. However, is there a connection to vitamin D and rheumatological issues?&nbsp;In a study published in&nbsp;Clinical Rheumatology,&nbsp;researchers aim to examine&nbsp;whether vitamin D levels are&nbsp;causally associated with risk of systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA).&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Mendelian randomization study finds no evidence of causal effect of vitamin D for risk of SLE <a href="https://twitter.com/hashtag/lupus?src=hash&amp;ref_src=twsrc%5Etfw">#lupus</a> or rheumatoid arthritis <a href="https://twitter.com/hashtag/RA?src=hash&amp;ref_src=twsrc%5Etfw">#RA</a> <a href="https://twitter.com/alhkim?ref_src=twsrc%5Etfw">@alhkim</a> <a href="https://twitter.com/psufka?ref_src=twsrc%5Etfw">@psufka</a> <a href="https://t.co/Uh0sFs6YXK">https://t.co/Uh0sFs6YXK</a>
&mdash; Jeffrey Sparks MD MMSc (@jeffsparks) <a href="https://twitter.com/jeffsparks/status/1031220856452784129?ref_src=twsrc%5Etfw">August 19, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Disappointed to see this finding, since a way to prevent would be nice&hellip; <a href="https://t.co/88ktfOByoS">https://t.co/88ktfOByoS</a>
&mdash; Paul Sufka, MD (@psufka) <a href="https://twitter.com/psufka/status/1031264144060821504?ref_src=twsrc%5Etfw">August 19, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>For the study,&nbsp;two-sample Mendelian randomization (MR) analyses using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods.&nbsp;Publicly available summary statistics datasets&nbsp;were used in the study, including&nbsp;two vitamin D level genome-wide association studies (GWASs) as exposure and SLE and RA GWASs on people of European descent as outcomes.&nbsp;&nbsp;The results&nbsp;showed that the IVW, weighted median, and MR-Egger regression methods yielded no evidence of a causal association between vitamin D level and risk of SLE (beta&thinsp;=&thinsp;0.032, SE&thinsp;=&thinsp;0.119, p&thinsp;=&thinsp;0.789; beta&thinsp;=&thinsp;0.233, SE&thinsp;=&thinsp;0.274, p&thinsp;=&thinsp;0.552; beta&thinsp;=&thinsp;0.054, SE&thinsp;=&thinsp;0.125, p&thinsp;=&thinsp;0.665; respectively) or RA (beta&thinsp;=&thinsp;0.026, SE&thinsp;=&thinsp;0.061, p&thinsp;=&thinsp;0.664; beta&thinsp;=&thinsp;0.025, SE&thinsp;=&thinsp;0.065, p&thinsp;=&thinsp;0.695; beta&thinsp;=&thinsp;0.025, SE&thinsp;=&thinsp;0.065, p&thinsp;=&thinsp;0.695; respectively).&nbsp;&ldquo;MR analysis did not support a causal association between the vitamin D level and SLE or RA,&rdquo; the researchers concluded.&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Mendelian randomization will provide some additional insight, too: <a href="https://t.co/XbDsupU50J">https://t.co/XbDsupU50J</a>
h/t <a href="https://twitter.com/jeffsparks?ref_src=twsrc%5Etfw">@jeffsparks</a>
&mdash; J. Brian Byrd Lab (@thebyrdlab) <a href="https://twitter.com/thebyrdlab/status/1031221617819561985?ref_src=twsrc%5Etfw">August 19, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>Check out&nbsp;an article on&nbsp;<a href="https://proddocwire.wpengine.com/docwire-pick/anaerobes-chronic-wound/">anaerobes in human&nbsp;chronic&nbsp;wounds</a>.&nbsp;SOURCE:&nbsp;<a href="https://link.springer.com/article/10.1007/s10067-018-4152-9">Clinical Rheumatology&nbsp;</a>

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Vitamin D Levels, Systemic Lupus Erythematosus, and Rheumatoid Arthritis

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Vitamin D is important to the health and wellness of one’s body. In order to absorb calcium and promote bone growth, one must have vitamin D. It also aids in the ...

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