Kaitlyn D’Onofrio

DocwireNews

Patients with severe cases of gout are at an increased risk of mortality. According to recent research, this risk is even more significant in gout patients with increased serum uric acid (sUA) levels.&nbsp;The goal of the present study was to determine if achieving&nbsp;sUA&nbsp;under 6 mg/dl, as opposed to greater, had an impact on mortality risk for gout patients. Researchers collected data on 1,193 gout patients&nbsp;(92% men, mean age 60, 6.8 years disease duration, with an average of 3 to 4 flares in the previous year)&nbsp;attending a specialized clinic between 1992 and 2017 who had at least one follow-up visit. They tracked&nbsp;sUA&nbsp;levels during follow-up, and &ldquo;and the average&nbsp;sUA&nbsp;until&nbsp;sUA&nbsp;was stable was used as the primary exposure dichotomized as &lt; 6 mg/dl (versus &gt; 6 mg/dl).&rdquo;&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
.<a href="https://twitter.com/GoutAlliance?ref_src=twsrc%5Etfw">@GoutAlliance</a>'s new video offers several tips for living with uncontrolled <a href="https://twitter.com/hashtag/gout?src=hash&amp;ref_src=twsrc%5Etfw">#gout</a>. <a href="https://t.co/cwuMgyPcjj">https://t.co/cwuMgyPcjj</a> <a href="https://t.co/L08Lc3VHzG">pic.twitter.com/L08Lc3VHzG</a>
&mdash; Alliance for Patient Access (@patientaccess) <a href="https://twitter.com/patientaccess/status/1053306597013946368?ref_src=twsrc%5Etfw">October 19, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>At baseline, mean&nbsp;sUA&nbsp;was 9.1 mg/dl, and 16.3% of patients had elevated&nbsp;sUA&nbsp;levels (&ge;6 mg/dl), even with treatment. Overall mortality was 13%, with 158 deaths, and 286 (24%) patients were lost to follow-up. The overall crude mortality rate was&nbsp;32.7 per 1,000 patient-years, (95%&nbsp;confidence interval [CI]: 28.0-38.2). Patients with elevated&nbsp;sUA&nbsp;levels had a significantly higher mortality risk (80.9 per&nbsp;1,000 person&nbsp;years,&nbsp;95% CI 59.4-110.3)&nbsp;than patients with&nbsp;sUA&nbsp;&lt;6 mg/dl (25.7 per 1,000 person-years, 95% CI: 21.3-30.9). When adjusting for age, sex, previous cardiovascular events, and&nbsp;sUA&nbsp;concentration at baseline, patients with increased&nbsp;sUA&nbsp;had a 139% increased risk of mortality compared to patients with&nbsp;sUA&nbsp;&lt;6 mg/dl.&nbsp;The findings of the study were presented at the annual meeting of the American College of Rheumatology by&nbsp;Fernando Perez-Ruiz, MD, PhD,&nbsp;a rheumatologist at Hospital Universitario Cruces,&nbsp;Barakaldo, Spain.&nbsp;&ldquo;Failure to reach a target&nbsp;sUA&nbsp;level of 6 mg/dl is an independent predictor of mortality in gout patients,&rdquo; the study authors wrote. &ldquo;Control of gout with achievement of&nbsp;sUA&nbsp;target &lt;6 mg/dl should be considered in order to improve patient survival.&rdquo;&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
AGA's new infographic explains how patients can manage uncontrolled <a href="https://twitter.com/hashtag/gout?src=hash&amp;ref_src=twsrc%5Etfw">#gout</a>: <a href="https://t.co/DhMlRFwzv5">https://t.co/DhMlRFwzv5</a> <a href="https://t.co/mny7BVwjej">pic.twitter.com/mny7BVwjej</a>
&mdash; Alliance for Gout Awareness (@GoutAlliance) <a href="https://twitter.com/GoutAlliance/status/1067476657278263296?ref_src=twsrc%5Etfw">November 27, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>The study demonstrates the need for a treat-to-target approach for gout patients, Perez-Ruiz&nbsp;<a href="https://www.mdedge.com/rheumatologynews/article/189349/gout/gout-new-data-support-treat-target-approach">said</a>&nbsp;at a press conference. Perez-Ruiz pointed out that this approach is already used in treating other diseases, such as diabetes and hypertension.&nbsp;&ldquo;A lot of physicians including, unfortunately, rheumatologists don&rsquo;t treat gout to target. They feel like if a patient is doing nicely, that&rsquo;s good enough. But it&rsquo;s like lowering cholesterol: If you&rsquo;re at 400 mg/dL and you go to 300, does that mean it&rsquo;s fine and you won&rsquo;t get a myocardial infarction?&rdquo;&nbsp;he said.&nbsp;<a href="https://proddocwire.wpengine.com/docwire-pick/gout-medication-associated-kidney/">Gout Medication Not Associated with Kidney Function Decline</a>&nbsp;<a href="https://proddocwire.wpengine.com/conference-coverage/acr-conference-coverage/research-identifies-independent-risk-factor-for-mortality-in-patients-with-gout/">Research Identifies Independent Risk Factor for Mortality in Patients with Gout</a>&nbsp;<a href="https://proddocwire.wpengine.com/abstracts/the-economic-burden-of-uncontrolled-gout-how-controlling-gout-reduces-cost/">The economic burden of uncontrolled gout: how controlling gout reduces cost</a>&nbsp;<a href="https://proddocwire.wpengine.com/abstracts/gout-patients-descriptive-qualitative/">mHealth App Patient Testing and Review of Educational Materials Designed for Self-Management of Gout Patients: Descriptive Qualitative Studies</a>&nbsp;Source:&nbsp;<a href="https://acrabstracts.org/abstract/failure-to-reach-serum-urate-target-is-associated-with-elevated-mortality-in-gout/">American College of Rheumatology</a>

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Patients with severe cases of gout are at an increased risk of mortality. According to recent research, this risk is even more significant in gout patients with increased ...

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