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Systemic sclerosis (SSc) is a disease of autoimmunity, fibrosis, and vasculopathy&mdash;with scleroderma renal crisis (SRC)&nbsp;being&nbsp;one of the most severe complications.&nbsp;In a study published in&nbsp;The Journal of Rheumatology, researchers aim to identify&nbsp;additional clinical characteristics and laboratory findings&nbsp;that&nbsp;could expand and improve the risk profile for future SRC at&nbsp;SSc&nbsp;diagnosis.&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Read more about the risk factors for <a href="https://twitter.com/hashtag/scleroderma?src=hash&amp;ref_src=twsrc%5Etfw">#scleroderma</a> renal crisis in <a href="https://twitter.com/hashtag/SystemicSclerosis?src=hash&amp;ref_src=twsrc%5Etfw">#SystemicSclerosis</a>. <a href="https://t.co/5dRNsws3Bg">https://t.co/5dRNsws3Bg</a>
&mdash; Rheumatology Advisor (@RheumAdvisor) <a href="https://twitter.com/RheumAdvisor/status/1026913403812671488?ref_src=twsrc%5Etfw">August 7, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Risk Factors for Scleroderma Renal Crisis in Systemic Sclerosis <a href="https://t.co/6S1qv42gLq">https://t.co/6S1qv42gLq</a> via <a href="https://twitter.com/RheumAdvisor?ref_src=twsrc%5Etfw">@RheumAdvisor</a> <a href="https://twitter.com/jrheum?ref_src=twsrc%5Etfw">@jrheum</a>
&mdash; The Journal of Rheumatology (@jrheum) <a href="https://twitter.com/jrheum/status/1026891657919094784?ref_src=twsrc%5Etfw">August 7, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>In this&nbsp;retrospective cohort study,&nbsp;the&nbsp;entire military electronic medical record between 2005 and 2016&nbsp;was&nbsp;compared&nbsp;for&nbsp;demographics, clinical characteristics, and laboratory results at&nbsp;SSc&nbsp;diagnosis for 31 cases who developed SRC after&nbsp;SSc&nbsp;diagnosis,&nbsp;to 322&nbsp;SSc&nbsp;without SRC disease controls.&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Risk Factors for <a href="https://twitter.com/hashtag/Scleroderma?src=hash&amp;ref_src=twsrc%5Etfw">#Scleroderma</a> <a href="https://twitter.com/hashtag/Renal?src=hash&amp;ref_src=twsrc%5Etfw">#Renal</a> Crisis in Systemic Sclerosis &ndash; <a href="https://t.co/FH2E7QT8Hv">https://t.co/FH2E7QT8Hv</a>
&mdash; DialysisSaves (@DialysisSaves) <a href="https://twitter.com/DialysisSaves/status/1026849453158932480?ref_src=twsrc%5Etfw">August 7, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>By the time of&nbsp;SSc&nbsp;diagnosis,&nbsp;conditions&nbsp;that were&nbsp;associated with future SRC&nbsp;included&nbsp;proteinuria (p &lt; 0.001; OR 183, 95% CI 19.1&ndash;1750), anemia (p = 0.001; OR 9.9, 95% CI 2.7&ndash;36.2), hypertension (p &lt; 0.001; OR 13.1, 95% CI 4.7&ndash;36.6), chronic kidney disease (p = 0.008; OR 20.7, 95% CI 2.2&ndash;190.7), elevated erythrocyte sedimentation rate (p &lt; 0.001; OR 14.3, 95% CI 4.8&ndash;43.0), thrombocytopenia (p = 0.03; OR 7.0, 95% CI 1.2&ndash;42.7), hypothyroidism (p = 0.01; OR 2.8, 95% CI 1.2&ndash;6.7), Anti-Ro antibody seropositivity&nbsp;(p = 0.003; OR 3.9, 95% CI 1.6&ndash;9.8), and ARA (p = 0.02; OR 4.1, 95% CI 1.2&ndash;13.8).&nbsp;&nbsp;&ldquo;These patients may benefit from close observation of blood pressure, proteinuria, and estimated glomerular filtration rate, for earlier SRC identification and intervention,&rdquo; the researchers concluded. &ldquo;Future prospective therapeutic studies could focus specifically on this high-risk population.&rdquo;&nbsp;&nbsp;Check out&nbsp;an article on&nbsp;how&nbsp;to&nbsp;<a href="https://proddocwire.wpengine.com/docwire-pick/preventing-active-tuberculosis/">prevent active tuberculosis</a>.&nbsp;SOURCE:&nbsp;<a href="https://www.rheumatologyadvisor.com/scleroderma/scleroderma-renal-crisis-risk-factors-in-systemic-sclerosis/article/785807/">Rheumatology Advisor</a>, <a href="http://www.jrheum.org/content/early/2018/07/09/jrheum.171186.long">The Journal of Rheumatology</a>&nbsp;

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Systemic Sclerosis Diagnosis: What Are the Risk Factors for Future Scleroderma Renal Crisis?

Rheumatology

Systemic sclerosis (SSc) is a disease of autoimmunity, fibrosis, and vasculopathy—with scleroderma renal crisis (SRC) being one of the most severe complications. In a ...