Study: Simple Drop of Blood May Detect Radiation Sickness

A single drop of blood may identify radiation sickness, according to the findings of a proof-of-concept study, published in journal Science Translational Medicine.

Radiation sickness, or acute radiation syndrome (ARS), is a deadly condition caused by irradiation of major volume or the entire body by a high dose of penetrating radiation in a very short time period – usually a matter of minutes. Historically, the effects of radiation sickness have been seen through accidental exposures or mass casualty radiologic events, like the ones witnessed in Hiroshima and Nagasaki during World War II or even a reactor accident such as the one at Chernobyl in 1986.

“This new test uses a single drop of blood – collected from a simple finger prick – and results are ready in a few hours. It is rapid, scalable and can serve as a point-of-care-type diagnostic tool for real-time evaluation to screen a large number of individuals in a short time,” says Naduparambil K. Jacob, PhD, an associate professor and scientist in the OSUCCC – James Translational Research Program in a press release.

For this test, researchers compare the relative expression of two small molecules called microRNAs in the blood. The first is microRNA-150 ¬- which Jacob’s lab identified several years ago as a biomarker to measure the extent of bone marrow damage. This microRNA decreases as a function of radiation dose while the normalizer, called microRNA-23a, does not change. Comparing these two molecular measures allows scientists to quantify the actual radiation dose absorbed, and therefore the overall exposure risk.

“We measure ionizing radiation in grays. People who are exposed to two gray need to be identified and treated and it is predicted that if you are exposed to about four gray to the whole body, without timely treatment there is a 50 percent chance of survival,” says Jacob.

Jacobs noted the test would have critical relevance in responding to mass casualty disaster scenario like that Chernobyl, to identify at-risk military personnel and civilians who need immediate treatment. Moreover, the tool is relevance for cancer patients, especially bone marrow transplant patients and others who have intense radiation therapy, where overdosing as well as underdosing is of concern.

Study: Single drop of blood could help rapidly detect radiation sickness – EurekAlert https://t.co/B4k7ivb2Kx • https://t.co/le73xfO7Nb

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“Some patients develop major issues like thrombocytopenia and neutropenia as the result of radiation treatment. We can’t look at a patient and determine how much radiation he or she has absorbed – but the impact can be cumulative. As a result, radiation sickness could occur weeks or months after the radiation therapy,” explains Jacob. “With additional research, this new testing method could potentially help oncologists measure – in real time – absorbed radiation and intervene before radiation sickness occurs.”

Study: Single drop of blood could help rapidly detect radiation sickness https://t.co/Rrh0grcO3b via @EurekAlert

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https://t.co/sQI73OtOs0https://t.co/WhDZCaLDtf https://t.co/T59lg6riVX

— Naduparambil Jacob (@njacob86) July 16, 2020