Rebecca Araujo

DocwireNews

A study of patients receiving treatment with <a href="https://docwirenews.com/post/tapering-steroids-prior-to-paclitaxel-for-breast-cancer-does-not-increase-infusion-reactions">paclitaxel</a> in an academic community hospital system found low rates of treatment-related hypersensitivity reactions (HSRs). These findings were presented at the <a href="https://www.hoparx.org/hopa-learn/conferences-events/" target="_blank" rel="noopener">Hematology/Oncology Pharmacy Association Annual Conference 2024</a>.The investigators performed a retrospective chart review for 200 inpatients and outpatients within the Memorial Healthcare System. The primary outcome was the incidence of paclitaxel HSRs. The secondary outcome was time to HSRs. Other outcomes analyzed were rates of paclitaxel re-challenge and rates of switching therapies.The most common malignancy was of the breast (56.0%), followed by gynecologic (26.0%), lung (10.5%), and other (8.0%). Only 16.5% of patients completed titration per Memorial Health System protocol (begin infusion at a 50% rate for 15 minutes, then proceed to increase to full rate if no reaction occurs).Ten (5%) patients experienced an HSR, of whom 60% were anaphylactic. Seventy percent of HSRs occurred within 15 minutes of infusion. Five patients who had an HSR had a therapy switch: 4 to nab-paclitaxel and 1 to a longer infusion time.&ldquo;Dose ranges of premedications fell below recommended doses within the package insert,&rdquo; the authors noted. Additionally, the &ldquo;majority of premedications were given outside the recommended administration time range, questioning appropriate use based on the dosage form and half-life of premedications.&rdquo;Overall, the incidence of HSRs fell below rates published in the literature (31%-45%), despite the low percentage of titration per health system protocol. &ldquo;Potential improvements to the standardization of paclitaxel administration protocol include removing titration instructions and acetaminophen for prophylaxis in paclitaxel protocols,&rdquo; the authors noted.<h4>Reference</h4>Kim MJ, Osmon E, Rodriguez M, Graibe-Martinez D. Incidence of paclitaxel hypersensitivity reactions at an academic community hospital system. Poster. Presented at the Hematology/Oncology Pharmacy Association Annual Conference 2024; April 3-6, 2024; Tampa, Florida.

Eric Bergson, MD

Rob Dillard

The Role of Multidisciplinary Care in Head and Neck Cancer

Head and Neck Cancer

Sara Nunnery, MD, MSCI

Trastuzumab Deruxtecan in HER2-Low Breast Cancer: Who’s the Right Patient?

HER2 Breast Cancer

Meghan Sise, MD

Joel M. Topf, MD, FACP

Redefining Carboplatin Dosing

NKF Spring Clinical Meetings 2025

Latest News

Study Investigates Rates of Paclitaxel Hypersensitivity Reactions in a Community Hospital System

HOPA Annual Conference 2024

Among patients receiving treatment with paclitaxel in an academic community hospital system, rates of treatment-related hypersensitivity reactions were low.

Rates of Paclitaxel Hypersensitivity Reactions in a Community Hospital System

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HR Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe