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A mixed-method study of Dutch patients, presented at the 63rd American Society of Hematology Annual Meeting &amp; Exhibition, examined treatment preferences among patients with Waldenstr&ouml;m macroglobulinemia (WM).This study comprised a literature review, qualitative interviews, and expert discussions. A discrete choice experiment questionnaire was developed to assess treatment-related characteristics, including:<ul>
<li>five-year progression-free survival (PFS)</li>
<li>frequency and type of administration (intravenous, subcutaneous, or oral)</li>
<li>treatment setting (clinic or home)</li>
<li>adverse events</li>
<li>risk of future secondary malignancies</li>
<li>type of treatment agent (chemotherapy or targeted therapy)</li>
</ul>Respondents were presented with two hypothetical, but realistic, treatment options and asked to choose between them. Questionnaires were disseminated nationally either online, via a patient organization&rsquo;s website, or paper assessments completed at outpatient clinics.In total, 330 online and 17 paper-based questionnaires were completed; 214 (65%) had complete data and were included in the analysis. The average age of respondents was 66 years, and 54% of the cohort were male. Average time since diagnosis was 6.9 years. Regarding disease status, 31% were in the wait-and-see period, 39% were in remission, 10% had progressive disease, and 20% were currently being treated.Respondents rated five-year PFS as the most important attribute for making treatment decisions. The probability of choosing a treatment option increased by 26% if the five-year PFS rate rose from 50% to 70%. The risk of secondary malignancies was the second most highly rated attribute. Selection of a treatment rose by 22% if the chance of secondary malignancy decreased from high to low. Risk of neuropathy was a greater consideration compared to nausea, vomiting, and extreme fatigue. To avoid risk of neuropathy, patients were willing to accept a 7.2% reduction in treatment efficacy. Selection of a treatment was 8% more likely with a fixed-duration, intravenous/subcutaneous administration at a hospital compared to an ongoing oral regimen at home.The authors reported that patients&rsquo; demographic characteristics and treatment status were not significantly associated with treatment preferences. However, educational status was the one exception: patients with a higher education status were more accepting of a treatment with a lower five-year PFS than patients with lower education levels (p &lt; 0.0001). Those with higher education tended to prefer targeted therapy and treatments with low risk of secondary malignancy (p &lt; 0.0001).&ldquo;These are the first data on WM patients&rsquo; preferences on treatment characteristics,&rdquo; wrote the authors in conclusion. &ldquo;These data can be used in discussions with individual patients about their treatment preference and help direct future clinical trials that optimally connect to WM patients&rsquo; preferences.&rdquo;

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A mixed-method study of Dutch patients, presented at the 63rd American Society of Hematology Annual Meeting &amp; Exhibition, examined treatment preferences among patients ...

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