Cailin Conner

DocwireNews

Gout is a form of inflammatory arthritis caused by the deposition of monosodium urate crystals in and around the joints and is characterized by severe gout flares that can last several days or week. The incidence of gout increases with age and carries strong associations with several comorbidities such as hypertension, stroke, obesity, type 2 diabetes, and chronic kidney disease. More recently, there has been special attention paid to the potential associations between gout and osteoporosis.Osteoporosis, primarily affecting the elderly population, is characterized by lowered bone density and enhanced bone fragility. This bone fragility leaves patients at a significantly increased risk for fractures. Previous studies have hypothesized that monosodium urate crystal-related inflammation may cause worse outcomes on bones by stimulating complex inflammatory signaling pathways and pro-inflammatory molecules.A retrospective study with a longitudinal 13-year follow-up was conducted to further investigate this association and determine whether such a link exists between gout and risk of developing osteoporosis. &ldquo;We explored the possible link between gout and incident osteoporosis/osteoporotic fractures based on long-term follow-up nationwide data,&rdquo; the authors of the study wrote in <a href="https://www.mdpi.com/2072-6643/15/1/134" target="_blank" rel="noopener">Nutrients</a>.A total of 16,305 patients with gout and 65,220 controls comprised the study population. Through propensity matching, gout patients were matched at a 1:4 ratio on the basis of sex, age, and income. The researchers then utilized a Cox proportional hazard model to identify the relevance between gout and incident osteoporosis and/or fractures.Osteoporosis developed in 761 individuals with gout, and the incidence rate of the development of osteoporosis in individuals with gout was 8.0/1,000 person-years. Comparatively, 2,805 controls developed osteoporosis, and the incidence rate was 7.3/1,000 person-years. After adjusting for confounding variables, individuals with gout had an 11% higher development of osteoporosis compared with controls. Additionally, subgroup analyses demonstrated a particular increase in the incident in osteoporosis in gout sufferers who were male or aged &lt;60 years.&ldquo;Our results may cautiously inform the modestly increased likelihood of incident osteoporosis in a subset of patients with gout during a long-term follow-up,&rdquo; the authors stated. &ldquo;Therefore, patients with gout may require screening for the early detection and appropriate treatment of osteoporosis as an avenue to manage gout.&rdquo;

Bradley Marder, MD

Joel M. Topf, MD, FACP

Gout Studies: Transplant Waitlisting and Bone Erosion

NKF Spring Clinical Meetings 2025

Jayme Locke, MD, MPH

The Promise of Xenotransplantation

Leah Lawrence

Real-World Data Backs Invasive DFS as Surrogate Endpoint for OS in EBC

HR Breast Cancer

Latest News

Study Finds Increased Risk of Osteoporosis in Patients With Gout

Nephrology Times

Gout is a form of inflammatory arthritis caused by the deposition of monosodium urate crystals in and around the joints and is characterized by severe gout flares that can ...

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

HER2 Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe