Kerri Fitzgerald

DocwireNews

Regular use of aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) improved survival in patients with <a href="https://proddocwire.wpengine.com/abstracts/ultrasound-in-the-re-staging-of-cervical-metastases-after-chemoradiotherapy-for-head-and-neck-cancer/">head and neck</a> squamous cell carcinoma (HNSCC) with PIK3CA mutations or amplification, according to a study published in the Journal of Experimental Medicine.Researchers evaluated 266 patients with HNSCC from a single center.Among those with PIK3CA mutations or amplification, regular NSAID use (defined as &ge;6 months) was associated with prolonged disease-specific survival (DSS; hazard ratio [HR] = 0.23; 95% CI, 0.09-0.62; P = 0.0032) and overall survival (OS; HR=0.31; 95% CI, 0.14-0.69; P = 0.0043) compared with patients who did not regularly use NSAIDs.<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Use of non-steroidal anti-inflammatory drugs, or NSAIDs, significantly improves survival for a third or more patients with head and neck cancer, shows a new study published in <a href="https://twitter.com/JExpMed?ref_src=twsrc%5Etfw">@JExpMed</a> (<a href="https://t.co/b9uwZn01oV">https://t.co/b9uwZn01oV</a>). Read news coverage in The <a href="https://twitter.com/Independent?ref_src=twsrc%5Etfw">@Independent</a>: <a href="https://t.co/5Q892irl1q">https://t.co/5Q892irl1q</a>
&mdash; Rockefeller U. Press (@RockUPress) <a href="https://twitter.com/RockUPress/status/1089987740790345728?ref_src=twsrc%5Etfw">January 28, 2019</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>Predicted five-year DSS was 72% for NSAID users and 25% for non-users among patients with PIK3CA-altered HNSCC (HR=0.24; P = 0.0032). Predicted five-year OS was 78% and 45%, respectively.Aspirin was a component of the NSAID regimen in 93% of regular users, and 73% used aspirin exclusively. Most regular users (86%) began NSAID therapy after being diagnosed with HNSCC.&ldquo;These findings uncover a biologically plausible rationale to implement NSAID therapy in PIK3CA-altered <a href="https://proddocwire.wpengine.com/abstracts/effect-pregabalin-radiotherapy-neuropathic/">HNSCC</a>,&rdquo; the researchers concluded.&nbsp;&nbsp;Source: <a href="http://jem.rupress.org/content/early/2019/01/25/jem.20181936">Journal of Experimental Medicine</a>

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Study Find NSAIDs Improve Survival in Head and Neck Cancer

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Regular use of aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) improved survival in patients with head and neck squamous cell carcinoma (HNSCC) with PIK3CA ...

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