Victoria Socha

DocwireNews

According to Cynthia Delgado, MD, and colleagues, there are few data available on differences in serum creatinine concentration between Black and non-Black individuals. To date, those differences among groups defined by race and ethnicity have been attributed to differences in muscle mass.&nbsp;The researchers conducted a data analysis to examine differences in serum creatinine by race and ethnicity in a cohort of patients receiving hemodialysis, and to determine whether the differences persisted following adjustment for proxies of muscle mass. The analysis included data on 501 participants in the ACTIVE/ADIPOSE (A Study to Investigate the Value of Exercise in ESKD/Analyses Designed to Investigate the Paradox of Obesity and Survival in ESKD) study. Eligible participants had been receiving hemodialysis for more than 1 year.&nbsp;The researchers sought to examine the independent associations among race/ethnicity (Black, Asian, non-Hispanic White, and Hispanic), serum creatinine, and intracellular water (ICW; L/m2; a proxy for muscle mass). The associations were identified using multivariable linear regression with adjustment for several demographic, clinical, and laboratory characteristics. ICW was derived by whole-body multifrequency bioimpedance spectroscopy. The association of race and ethnicity with serum creatinine concentration was examined with and without adjustment for ICW.&nbsp;Serum creatinine concentrations were higher among Black, Asian, and Hispanic patients compared with non-Hispanic White patients (+1.68 mg/d; +1.61 mg/dL; +0.83 mg/dL, respectively). Overall, there was an association between ICW and serum concentration (0.26 ng/dL per L/m2 ICW). The association was not statistically significantly different by race and ethnicity. After adjustment for ICW, the association between Black, Asian, and Hispanic race/ethnicity and serum creatinine concentration remained significant.&nbsp;&ldquo;Among patients receiving dialysis, serum creatinine was higher in Black, Asian, and Hispanic patients than in non-Hispanic White patients,&rdquo; the researchers said. &ldquo;Differences in ICW did not explain the differences in serum creatinine concentration across race groups.&rdquo;&nbsp;Source: <a href="https://www.doi.org/10.1681/ASN.0000000000000240" target="_blank" rel="noopener">Journal of the American Society of Nephrology</a>

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Researchers studied differences in serum creatinine concentration between Black and non-Black patients on hemodialysis.

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