Victoria Socha

DocwireNews

Patients undergoing kidney transplantation are at risk for new-onset diabetes after transplantation (NODAT). NODAT is a common complication after kidney transplantation; however, according to researchers in the Republic of Korea, the mechanism of NODAT is not fully understood. Results of recent studies suggest that in the general population gut bacteria play a key role in diabetes.The researchers, led by K. Ji Eun, conducted a study designed to examine the gut microbiota on NODAT in kidney transplant recipients. Results of the study were reported during a poster <a href="https://atcmeetingabstracts.com/abstract/proportion-of-veillonella-and-the-risk-of-new-onset-diabetes-mellitus-after-kidney-transplantation/">session</a> at the virtual American Transplant Congress 2020 in a poster titled Proportion of Veillonella and the Risk of New-Onset Diabetes Mellitus after Kidney Transplantation.Stool samples were collected from 46 transplant recipients at three time points: prior to transplantation, 3 months following transplantation, and 12 months following transplantation. Stool DNA extraction and 16s DNA metagenome sequencing were performed. The development of post-transplantation diabetes mellitus was defined as hemoglobin A1c level &ge;6.5% or initiation of the use of diabetes medications.Of the 46 transplant recipients, 11 were diagnosed with pre-transplant diabetes mellitus. During follow-up of 2.1 years, 15 of the remaining 35 patients were diagnosed with NODAT.Results of the 16s DNA analysis showed significant differences among patients without diabetes, those with NODAT, and those with pre-transplant diabetes in change of abundance in genus Veillonella according to the time after transplant. In patients without diabetes, there was a significant increase in the proportion of Veillonella at 3 months post-transplant; there was no increase in patients with NODAT or pre-transplant diabetes.In unadjusted analysis, patients with reduced abundance of Veillonella at 3 months post-transplant compared with 3 months pre-transplant had a 6.0-fold increased risk of developing NODAT compared with those without reduced abundance of Veillonella (hazard ratio [HR], 6.00; 95% confidence interval [CI], 1.87-19.2; P=.003). Following adjustment for age, sex, body mass index, dialysis duration, and desensitization, the adjusted HR was 5.85 (95% CI, 1.62-21.28), P=.007.&ldquo;The reduction of Veillonella at 3 months after transplantation is significantly associated with NODAT,&rdquo; the researchers said.Source: Eun KJi, Kim H, Cho H, et al. Proportion of Veillonella and the Risk of New-Onset Diabetes Mellitus after Kidney Transplantation. Abstract of a poster presented at the virtual American Transplant Congress 2020 (Abstract B-047), May30, 2020.

Bradley Marder, MD

Joel M. Topf, MD, FACP

Gout Studies: Transplant Waitlisting and Bone Erosion

NKF Spring Clinical Meetings 2025

Jayme Locke, MD, MPH

The Promise of Xenotransplantation

Leah Lawrence

Real-World Data Backs Invasive DFS as Surrogate Endpoint for OS in EBC

HR Breast Cancer

Latest News

Risk of New-Onset Diabetes after Kidney Transplantation and Proportion of Veillonella

American Transplant Congress 2020

Patients undergoing kidney transplantation are at risk for new-onset diabetes after transplantation (NODAT). NODAT is a common complication after kidney transplantation; ...

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HER2 Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe