Kaitlyn D’Onofrio

DocwireNews

A recent study assessed the risk of disease recurrence and <a href="https://www.docwirenews.com/docwire-pick/hem-onc-picks/the-effect-of-the-opioid-epidemic-on-cancer-survivors/">survival</a> in multiple myeloma patients, using a conditional survival approach.&ldquo;Unlike the traditional method of overall survival prediction in patients with cancer, conditional survival predicts the survival of patients dynamically throughout the course of disease, identifying how a prognosis evolves over time,&rdquo; the researchers explained.They identified 815 consecutive <a href="https://www.docwirenews.com/conference-coverage/2020-hopa-annual-conference/multiple-myeloma-patients/">multiple myeloma patients</a> using the German Study Group on Multiple Myeloma (Deutsche Studiengruppe Multiples Myelom; DSMM) incentive. More than 10 variables were assessed upon diagnosis and on numerous occasions during follow-up; these variables included patient- and multiple myeloma-specific measures. Disease- and host-related risks were used to calculate the odds of five-year survival.Median follow-up and overall survival were 10.3 years and 5.1 years, respectively. Five-year conditional survival probabilities significantly changed when using data collected at the initial diagnosis updated overtime versus using follow-up data. When analyzing multivariate Cox regression models, the hazard ratio (HR) for surviving 0 to 5 years was 1 for patients aged &lt;60 years. HRs for patients aged 60 to 69 years and &gt;70 years were 1.68 and 3.17, respectively. Factors associated with declining HRs for age were surviving five years, having advanced stages of disease (II/III), and having unfavorable cytogenetics; progressive disease significantly impacted HRs for survival at one year (1.85), three years (2.11), and five years (2.14).The study was published in <a href="https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.32978">Cancer</a>.&ldquo;To the authors&rsquo; knowledge, the current study is the first analysis of conditional survival in patients with multiple myeloma using both baseline and follow&#8208;up risk parameters, demonstrating that regular risk assessment throughout the course of disease and complete follow&#8208;up provide a more reliable conditional survival estimation than baseline assessment alone,&rdquo; the researchers summarized.

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Researchers Use Conditional Survival Approach to Assess Disease Recurrence Risk and Survival in Multiple Myeloma

Oncology

A recent study assessed the risk of disease recurrence and survival in multiple myeloma patients, using a conditional survival approach. ...

Researchers Use Conditional Survival Approach to Assess Disease Recurrence Risk and Survival in

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