Victoria Socha

DocwireNews

Researchers, led by Rubeen K. Israni, 
MD, recently conducted a study among people with mild hyperkalemia to 
identify the time to progression from mild hyperkalemia to moderate-to-severe 
or severe hyperkalemia. Results were reported during a poster session at Kidney 
Week 2019 in a poster titled Hyperkalemia Progression Rates among Patients 
with Mild Hyperkalemia.The researchers examined data from 
electronic health records from the Research Action for Health Network (2012-2018). 
Eligible patients had a minimum of one mild hyperkalemia event, defined as 
serum potassium &gt;5.0 and &le;5.5 mEq/L.&nbsp; 
The index date was defined as the date of the first mild hyperkalemia 
event. Patients had to have a minimum of one additional serum potassium 
laboratory value during the study period (2 years post-index date).Progression to moderate-to-severe 
hyperkalemia and to severe hyperkalemia was defined as the first occurrence of 
a serum potassium laboratory value &gt;5.5 mEq/L and &gt;6.0 mEq/L, 
respectively. Rates of progression over the study period for the overall study 
population were estimated using Kaplan-Meier analyses. Analyses were also 
performed among patient subgroups, including patients with and without chronic 
kidney disease (CKD stages 3-5), heart failure, hypertension, or type 2 
diabetes.The analysis included 35,369 patients 
with mild hyperkalemia. Mean age of the cohort was 65.6 years and 47.5% were 
women. At the end of the study period, 16.9% of patients progressed to 
moderate-to-severe hyperkalemia and 8.7% progressed to severe hyperkalemia. 
Among the subgroups, rates of hyperkalemia progression were higher in patients 
with CKD, heart failure, hypertension, and diabetes compared with patients 
without those conditions (all log-rank P&lt;.001). As CKD stage 
progressed, there were significant increases in the rate of hyperkalemia 
progression (P&lt;.001).In conclusion, the researchers said, 
&ldquo;A total of 16.9% of patients with mild hyperkalemia experienced hyperkalemia 
progression during the 2-year follow-up period. Hyperkalemia progression rates 
increased significantly with CKD stage and were also higher among those with 
heart failure, hypertension, or type 2 diabetes.&rdquo;Source: Israni RK, David J, Betts K, 
et al. Hyperkalemia progression rates among patients with mild hyperkalemia. 
Abstract of a poster presented at the American Society of Nephrology Kidney 
Week 2019 (Abstract FR-PO648), November 8, 2019, Washington, DC.

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Latest News

Progression Rates of Hyperkalemia Increase with CKD Stage

Chronic Kidney Disease

A study among people with mild hyperkalemia to identify the time to progression from mild hyperkalemia to moderate-to-severe or severe hyperkalemia. 

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