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Two posters to be presented at AAO 2019 will look at safety and satisfaction associated with intravitreal implants and intravitreal injections, respectively.The first, &ldquo;Global Safety Update: Long-Term IOP Outcomes in Patients Receiving the Fluocinolone Acetonide Intravitreal Implant,&rdquo; presents data from the 2018 Periodic Safety Update Report/ Periodic Benefit Risk Evaluation Report (PSUR/PBRER), which evaluated real-world, long-term safety data for the fluocinolone acetonide (FAc) intravitreal implant (Iluvien). The August 2018 PSUR/PBRER for FAc implant encompasses data from the U.S.-based Phase 4 IOP Signals Associated with ILUVIEN Study (PALADIN), U.S. retrospective chart review (USER), and non-U.S. studies (Retro IDEAL, IRISS and MEDISOFT), as well as global spontaneous reporting data.The research included 18,082 eyes that received an FAc intravitreal implant; 69 (0.38%) eyes required incisional surgery. Per data from the FAME trials, out of 375 eyes, 18 (4.8%) required incisional surgery. The FAME trials reported a higher rate of trabeculoplasty (n = 4, 1.1%) than the PSUR/PBRER (n = 40, 0.22%).&ldquo;The PSUR/ PBRER did not identify any significant safety signals that would potentially impact the FAc implant safety profile,&rdquo; the researchers concluded. &ldquo;These data confirm IOP safety outcomes of the FAc implant across multiple countries and DME labels.&rdquo;The second scientific poster, &ldquo;Assessing Patient Comfort and Antimicrobial Efficacy Using Aqueous Chlorhexidine vs. Povidone Iodine Prior to Bilateral Intravitreal Injection,&rdquo; acknowledged that povidone iodine is a common antiseptic used in intravitreal injections but often causes discomfort, whereas aqueous chlorhexidine has been more well-tolerated. The randomized study compared the two techniques.The patient population included participnts receiving bilateral intravitreal injections with either povidone iodine or aqueous chlorhexidine antiseptic. Researchers performed a bacterial culture before and after antiseptic use, and a standardized ocular staining score (OSS) was used to record a fluorescein exam. Pain was self-reported using a 10-point scale one minute and one day after the procedure.Final analysis included 100 eyes of 50 patients. The povidone iodine eyes reported a greater post-injection pain score (P &lt; 0.001), as well as greater OSS (P &lt; 0.001). Adverse events and culture positivity rates did not differ between the groups.

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Patient Safety and Comfort in Intravitreal Administrations

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Two posters to be presented at AAO 2019 will look at safety and satisfaction associated with intravitreal implants and intravitreal injections, respectively. ...

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