Victoria Socha

DocwireNews

Previously, hepatitis C positive (HVC+) donor kidneys were only transplanted into recipients who were HCV infected (D+/R+). The emerging availability of direct acting anti-viral (DAA) medications has enabled the transplantation of an HCV positive kidney into a non-infected recipient (D+/R-).J. Torabi and colleagues at Montefiore Medical Center, Bronx, New York, conducted an analysis to compare center waitlist times and total waitlist allocation days between a cohort of HCV positive patients who were transplanted with donor positive kidneys (D+/R+) (n=29) with a cohort of patients who were HCV negative and received a donor positive kidney (D+/R-) (n=40). Following transplantation, D+/R- recipients were treated with DAAs.Results of the analysis were reported during a virtual poster session at the American Transplant Congress 2020 in a poster titled Transplantation of HCV Positive Kidneys Confers Excellent Outcomes for HCV Infected and Uninfected Recipients.The D+/R- cohort had older recipient and donor age compared with the D+/R+ cohort: 66.9 years vs 60.8 years (P=.02) and 35.1 years versus 29.9 years (P=.01), respectively. The Kidney Donor Profile Index was also significantly higher in the D+/R- group than in the D+/R+ group (60.9 vs 44.9; P=.01).There were no statistically significant differences in waitlist times between the two groups in either total allocation time (1340 days in the D+/R- group vs 1209 days in the D+/R+ group; P=.61) or center waitlist days (745 days in the D+/R- group vs 543 days in the D+/R+ group; P=.28). All D+/R- patients developed HCV viremia following transplantation, but with DAA treatment achieved sustained virologic response within 12 weeks.There were no significant differences in length of stay between the D+/R- group and the D+/R+ group (5.1 vs 6.1; P=.33) or incidence of delayed graft function (28% vs 38%; P=.36). Creatinine and estimated glomerular filtration rate at 1 and 6 months were similar in both groups. All patients tolerated DAA treatment with no adverse effects from treatment.In summary, the researchers said, &ldquo;Transplantation of HCV positive kidneys offers excellent <a href="https://www.docwirenews.com/latest-nephrology-news/outcomes-among-recipients-of-kidney-allografts-from-donors-with-hypertension/">outcomes</a> in both HCV positive and negative recipients.&rdquo;Source:&nbsp; Torabi J, Muhdi N, Montal A,et al. Transplantation of HCV positive kidneys confers excellent outcomes for HCV infected and uninfected recipients. Abstract of a poster presented at the virtual American Transplant Congress 2020 (Abstract A-044), May 30, 2020.

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Outcomes in HCV Positive and Negative Recipients of HCV Positive Kidney

American Transplant Congress 2020

Previously, hepatitis C positive (HVC+) donor kidneys were only transplanted into recipients who were HCV infected (D+/R+). The emerging availability of direct acting ...

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