Cailin Conner

DocwireNews

The cumulation of uric acid (UA) results in elevated levels of serum UA (SUA), otherwise known as hyperuricemia. When SUA becomes insoluble in the blood, monosodium urate (MSU) crystals are subsequently formed and deposit in and around the joints. Gout, an inflammatory arthritis, presents as immune responses in reaction to the deposition of MSU crystals. Gout has been linked with comorbidities such as hypertension, coronary artery disease (CAD), chronic kidney disease (CKD), obesity, and type 2 diabetes.Characterized by recurrent bouts of upper airway obstruction during sleep, obstructive sleep apnea (OSA) is a severe sleep disorder the leads to intermittent hypoxia. Oxidative stress and chronic inflammation as a result of gout symptoms are major pathogenic factors of OSA. In addition, several observational epidemiological studies have reported that patients with OSA have higher levels of SUA.Published in <a href="https://www.sciencedirect.com/science/article/abs/pii/S0049017222001469?via%3Dihub#preview-section-abstract" target="_blank" rel="noopener">Seminars in Arthritis and Rheumatism</a>, researchers conducted a series of observational studies reporting on the close associations of OSA with SUA levels and gout. Utilizing bidirectional univariable and multivariate Mendelian randomization (MR) based on publicly available genome-wide association studies, researchers investigated whether OSA is causally related to SUA levels, gout and vice versa. They also evaluated the independent causal effect of OSA on SUA and gout after adjusting for factors such as BMI type 2 diabetes, CAD, and CKD.The univariable MR method showed that genetically predicted OSA liability was significantly associated with increased levels of SUA and risk of gout. The results of multivariate Mendelian randomization suggested that while OSA retained its significant association with increased SUA levels, the significant association between OSA and gout was nonexistent after adjusting for body mass index and type 2 diabetes. However, researchers noted that there was &ldquo;no causal effect of OSA on SUA levels and gout was found in the reverse direction.&rdquo;

MarkAlain Déry, DO

The Significant Danger Measles Pose for Unvaccinated Children

Infectious Disease

Andrew Moreno

Antithrombotic Care in Hemophilia: A Summary of Multi-Organizational Clinical Practice Guidance

Hemophilia

James Tumlin, MD

Joel M. Topf, MD, FACP

Proteinuria Remission With Sparsentan in FSGS

NKF Spring Clinical Meetings 2025

Latest News

Obstructive Sleep Apnea Found to Be Causally Associated With Increased Serum Uric Acid Levels

Nephrology Times

The cumulation of uric acid (UA) results in elevated levels of serum UA (SUA), otherwise known as hyperuricemia. When SUA becomes insoluble in the blood, monosodium urate ...

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

HER2 Breast Cancer

HR Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe