According to a study published in The Journal of Orthopaedic Research, non-invasive collection of biomarkers could be a possible method of predicting a patient’s risk of osteolysis. Researchers assessed biomarkers present in urine samples from 26 patients who had total hip replacements, 16 of whom having osteolysis after operation. Biomarkers were examined annually for 6 years before diagnosis, prior to operation, and at the first sampling point after operation.
Of the 7 candidate biomarkers observed, free deoxypyridinoline was most strongly related to risk of osteolysis, with an area under the curve (AUC) in Receiver Operating Characteristic (ROC) analyses of 0.844 at 6 years prior to diagnosis. An α‐crosslaps and interleukin‐6 containing panel identified those who were at risk of osteolysis with an AUC > 0.941 at all biomarker collections after operation, and an AUC of 1.0 before operation.
These results display the potential use of noninvasive biomarkers in determining a patient’s risk for osteolysis after arthroplasty. The simplicity of the urine sample makes the diagnosis a practical and inexpensive procedure that can identify risk of osteolysis before it is present on radiographic imaging.
Source: Journal of Orthopaedic Research
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