Nonbacterial Osteomyelitis in Humans: An Update

Chronic recurrent multifocal osteomyelitis (CRMO) is a complex genetic disorder and in the past, several single gene defects (LPIN2, Pstpip2 and IL1RN) that cause IL-1-mediated sterile multifocal osteomyelitis have been discovered. 

New studies provide evidence that Majeed syndrome is an NLRP3 inflammasomopathy, and new gene discoveries include the identification of FBLIM1 as a CRMO susceptibility gene. In this Current Opinion in Rheumatology, a full update on the genetics of nonbacterial osteomyelitis is provided. 

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SOURCE: Current Opinion in Rheumatology