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By definition, rheumatic&nbsp;diseases are disorders with the presence of inflammation, as well as the destruction of joints and internal organs.&nbsp;Autoantibodies targeting molecules&nbsp;are&nbsp;commonly expressed in neutrophils&nbsp;within these types of diseases.&nbsp;&nbsp;Neutrophils&nbsp;initiate a cell death mechanism termed neutrophil extracellular trap (NET) formation&nbsp;as a way to&nbsp;ensnare pathogens.&nbsp;In this review by&nbsp;Nature Reviews Rheumatology,&nbsp;researchers&nbsp;highlight the mechanisms required for the generation of&nbsp;NETs&nbsp;and&nbsp;discuss the role of neutrophils and NETs in systemic lupus erythematosus, vasculitis (specifically anti-neutrophil cytoplasmic autoantibody-associated vasculitis), rheumatoid arthritis and gout.&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Our new <a href="https://twitter.com/hashtag/review?src=hash&amp;ref_src=twsrc%5Etfw">#review</a> on the function of <a href="https://twitter.com/hashtag/NETs?src=hash&amp;ref_src=twsrc%5Etfw">#NETs</a> in rheumatic diseases is online now! <a href="https://twitter.com/hashtag/SLE?src=hash&amp;ref_src=twsrc%5Etfw">#SLE</a> <a href="https://twitter.com/hashtag/vasculitis?src=hash&amp;ref_src=twsrc%5Etfw">#vasculitis</a> <a href="https://twitter.com/hashtag/gout?src=hash&amp;ref_src=twsrc%5Etfw">#gout</a> <a href="https://twitter.com/hashtag/rheumatoidarthritis?src=hash&amp;ref_src=twsrc%5Etfw">#rheumatoidarthritis</a><a href="https://t.co/KGjjOe4EMT">https://t.co/KGjjOe4EMT</a> <a href="https://t.co/U812FEnE36">pic.twitter.com/U812FEnE36</a>
&mdash; NatRevRheumatol (@NatRevRheumatol) <a href="https://twitter.com/NatRevRheumatol/status/1009806211372535808?ref_src=twsrc%5Etfw">June 21, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
New to our <a href="https://twitter.com/hashtag/MostRead?src=hash&amp;ref_src=twsrc%5Etfw">#MostRead</a> list: our review on the role of neutrophil extracellular traps in rheumatic diseases <a href="https://twitter.com/hashtag/NETs?src=hash&amp;ref_src=twsrc%5Etfw">#NETs</a> <a href="https://twitter.com/hashtag/SLE?src=hash&amp;ref_src=twsrc%5Etfw">#SLE</a> <a href="https://twitter.com/hashtag/vasculitis?src=hash&amp;ref_src=twsrc%5Etfw">#vasculitis</a> <a href="https://twitter.com/hashtag/gout?src=hash&amp;ref_src=twsrc%5Etfw">#gout</a> <a href="https://twitter.com/hashtag/rheumatoidarthritis?src=hash&amp;ref_src=twsrc%5Etfw">#rheumatoidarthritis</a><a href="https://t.co/KGjjOe4EMT">https://t.co/KGjjOe4EMT</a> <a href="https://t.co/YBFPxzO5W3">pic.twitter.com/YBFPxzO5W3</a>
&mdash; NatRevRheumatol (@NatRevRheumatol) <a href="https://twitter.com/NatRevRheumatol/status/1013905525484982272?ref_src=twsrc%5Etfw">July 2, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>According to the review, molecules released during neutrophil extracellular trap (NET) formation can often become autoantigens in systemic lupus erythematosus, small vessel vasculitis, rheumatoid arthritis and gout.&nbsp;These damaged tissues and organs are prone to containing NET-derived material.&nbsp;According to the review, neutrophils from patients with some rheumatic diseases spontaneously undergo&nbsp;NETosis&nbsp;in vitro, but &ldquo;to date, whether NET formation is deleterious to progression of all rheumatic diseases is unclear,&rdquo;&nbsp;the&nbsp;researchers concluded.&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
NETS operate in many rheumatic diseases, including <a href="https://twitter.com/hashtag/gout?src=hash&amp;ref_src=twsrc%5Etfw">#gout</a> <a href="https://t.co/Uj1Cchq675">https://t.co/Uj1Cchq675</a>
&mdash; Tuhina Neogi, MD, PhD (@Tuhina_Neogi) <a href="https://twitter.com/Tuhina_Neogi/status/1014172889367613446?ref_src=twsrc%5Etfw">July 3, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>SOURCE:&nbsp;<a href="https://www.nature.com/articles/s41584-018-0039-z">Nature Reviews Rheumatology</a>&nbsp;

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