DocWire News Editors

DocwireNews

An open-label, single-arm, phase I clinical trial showed that teclistamab displayed promising effectiveness, a durable response, and was well tolerated in treating patients with relapsed or refractory multiple myeloma (MM). The study, led by Saad Zafar Usmani, MD, FACP, and colleagues, was published in The Lancet. Given the results from the study, the authors suggested that further clinical development of teclistamab is warranted.&nbsp;Patients with MM who were relapsed, refractory, or intolerant to established therapies were eligible to participate. Teclistamab was administered intravenously (range 0&middot;3-19&middot;2 &mu;g/kg [once every 2 weeks] or 19&middot;2-720 &mu;g/kg [once per week]), or subcutaneously (range 80-3000 &mu;g/kg [once per week]) in different cohorts, with step-up dosing for 38&middot;4 &mu;g/kg or higher doses. The study&rsquo;s objectives were to identify the recommended phase II dose, and to assess the safety and tolerability of teclistamab at that dose.&nbsp;Patients were screened for eligibility, and enrolled between June 8, 2017, and March 29, 2021. A total of 157 patients, with a median of six previous therapy lines, received at least one dose of teclistamab (intravenous n = 84; subcutaneous n = 73).&nbsp;A subgroup of 40 patients received the identified recommended phase II dose, once per week subcutaneous teclistamab at 1500 &mu;g/kg, after 60 &mu;g/kg and 300 &mu;g/kg step-up doses (median follow-up 6&middot;1 months, IQR 3&middot;6-8&middot;2). Among the subgroup, cytokine release syndrome (28 patients; 70%; all grade I or II events), and neutropenia (26 patients; 65%; grade III or IV in 16 patients [40%]) were the most common treatment-emergent adverse events. The overall response rate at the recommended dose was 65% (95% CI, 48-79), and 58% achieved a very good partial response or better.&nbsp;According to the authors, the results of the study provide support for teclistamab as an emergent treatment option for patients with relapsed or refractory MM, when administered at the recommended phase II dose.

Bradley Marder, MD

Joel M. Topf, MD, FACP

Gout Studies: Transplant Waitlisting and Bone Erosion

NKF Spring Clinical Meetings 2025

Jayme Locke, MD, MPH

The Promise of Xenotransplantation

Leah Lawrence

Real-World Data Backs Invasive DFS as Surrogate Endpoint for OS in EBC

HR Breast Cancer

Latest News

MajesTEC-1 Trial: Teclistamab for Relapsed or Refractory Multiple Myeloma

Oncology

An open-label, single-arm, phase I clinical trial showed that teclistamab displayed promising effectiveness, a durable response, and was well tolerated in treating patients ...

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HER2 Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe