Kaitlyn D’Onofrio

DocwireNews

A recent cohort study found that lupus nephritis patients with end-stage renal disease (LN-ESRD) may significantly decrease their mortality risk by undergoing a renal transplant.The study consisted of data from the United States Renal Data System on LN-ESRD patients who were put on a waitlist for a renal transplant. Primary outcomes were all-cause and cause-specific mortality. Researchers calculated hazard ratios (HRs) using time-dependent Cox regression analysis.<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Learn more about <a href="https://twitter.com/hashtag/KidneyTransplants?src=hash&amp;ref_src=twsrc%5Etfw">#KidneyTransplants</a> in patients with Lupus Nephritis in the latest <a href="https://twitter.com/hashtag/AnnalsPatientSummary?src=hash&amp;ref_src=twsrc%5Etfw">#AnnalsPatientSummary</a>: <a href="https://t.co/zfRO0bbLbj">https://t.co/zfRO0bbLbj</a>. <a href="https://t.co/GX8bp7FJNb">pic.twitter.com/GX8bp7FJNb</a>
&mdash; Annals of Int Med (@AnnalsofIM) <a href="https://twitter.com/AnnalsofIM/status/1088451649364885505?ref_src=twsrc%5Etfw">January 24, 2019</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>A total of 9,659 LN-ESRD patients were put on a renal transplant waitlist during the study period; 59% (n = 5,738) had a transplant. Waitlisted patients who underwent transplant had a lower all-cause morality risk (adjusted HR, 0.30 [95% CI, 0.27 to 0.33]). Cause-specific mortality adjusted HRs were as follows: cardiovascular disease, 0.26 (CI, 0.23 to 0.30); coronary heart disease, 0.30 (CI, 0.19 to 0.48); infection, 0.41 (CI, 0.32 to 0.52); and sepsis, 0.41 (CI, 0.31 to 0.53).https://twitter.com/DrJackieVolk/status/1087802244911771648One of the study&rsquo;s limitations is that other factors not measured by the researchers could be impacting the results; still, they wrote, &ldquo;the E-value analysis suggested robustness of the results.&rdquo;A previous <a href="https://www.ncbi.nlm.nih.gov/pubmed/28420067">study</a> also found good outcomes for LN-ESRD patients, specifically in a Latin American cohort. Researchers evaluated data from 65 kidney transplants in LN-ESRD patients; survival at one, 10, and 15 years was 98% (P = 0.99). Graft survival rates were 92% at one year, 83% at five years, and 71% at 15 years. Two (3.1%) patients experienced recurrent disease, and one patient diagnosed with recurrent LN died from an infection. When controlling for age and sex, survival rates were still 98% after 15 years; when controlling for donor, five-year survival was 100% and 15-year survival was 98%. Graft survival rates in age- and sex- controlled analysis were 90% at one year, 84% at five years, and 64% at 15 years, and in donor-controlled analysis for the same time period were 89%, 86%, and 79%, respectively (P = 0.7718).https://twitter.com/Lupusreference/status/1087961634352578561Researchers for the present study wrote of their findings, &ldquo;Renal transplant was associated with a survival benefit, primarily due to reduced deaths from cardiovascular disease and infection. The findings highlight the benefit of timely referral for transplant to improve outcomes in this population.&rdquo;<a href="https://proddocwire.wpengine.com/docwire-pick/lupus-nephritis-renal-disease/">Lupus Nephritis in End-stage Renal Disease Patients Declines</a><a href="https://proddocwire.wpengine.com/docwire-pick/voclosporin-lupus-nephritis-patients/">Voclosporin Add-on May Benefit Lupus Nephritis Patients</a><a href="https://proddocwire.wpengine.com/abstracts/mycophenolate-mofetil-versus-intravenous/">Efficacy and Safety of Mycophenolate Mofetil Versus Intravenous Pulse Cyclophosphamide as Induction Therapy in Proliferative Lupus Nephritis</a><a href="https://proddocwire.wpengine.com/abstracts/rheumatology-abstracts/japanese-patients-lupus-nephritis/">Remission of proteinuria under therapeutic intervention and the renal outcomes in Japanese patients with lupus nephritis class III and IV</a>Source:<a href="https://annals.org/aim/article-abstract/2722549/renal-transplantation-survival-among-patients-lupus-nephritis-cohort-study"> Annals of Internal Medicine</a>

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Lupus Nephritis Patients with End-stage Renal Disease Benefit from Transplant

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A recent cohort study found that lupus nephritis patients with end-stage renal disease (LN-ESRD) may significantly decrease their mortality risk by undergoing a renal ...

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