KDIGO Publishes Updated Guideline on Nephrotic Syndrome in Children

Kidney Disease: Improving Global Outcomes (KDIGO) has issued a new, updated guideline on the management of nephrotic syndrome in children. The previous guideline update was published in 2021.

In an executive summary published in Kidney International, the authors noted the significant addition of a treatment algorithm providing details on when to perform a kidney biopsy and/or genetic testing and which immunosuppressive therapy to prescribe for children with a complete response to glucocorticoids who experience infrequent or frequent relapses or become steroid dependent.

Another notable change is that various clinical scenarios have been defined to align with the International Pediatric Nephrology Association guideline on the management of children with steroid-sensitive and steroid-resistant nephrotic syndrome.

The full guideline is available on KDIGO’s website at kdigo.org/guidelines/nephrotic-syndrome-in-children.

Source: Floege J, et al. Kidney Int. 2025;107(5):806-808. doi:10.1016/j.kint.2024.11.006