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In some cases, chronic inflammation (specifically juvenile idiopathic arthritis) can lead to some growth delays. In a study published in&nbsp;The Journal of Rheumatology, researchers evaluated the growth in patients with polyarticular-course juvenile idiopathic arthritis (pcJIA) treated with tocilizumab.&nbsp;In a phase III trial, patients with&nbsp;pcJIA&nbsp;who did not respond well to methotrexate received&nbsp;tocilizumab&nbsp;intravenously every 4 weeks (randomly assigned to 8 or 10 mg/kg if they weighed &lt; 30 kg; received 8 mg/kg if they weighed &ge; 30 kg) for 16 weeks.&nbsp;The study had 188 patients aged 2 to 17 years.&nbsp;&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Most Actemra-treated patients with polyarticular-course JIA increased in height <a href="https://t.co/esuyyPVkLk">https://t.co/esuyyPVkLk</a> <a href="https://twitter.com/jrheum?ref_src=twsrc%5Etfw">@jrheum</a>
&mdash; The Journal of Rheumatology (@jrheum) <a href="https://twitter.com/jrheum/status/1033014035032076289?ref_src=twsrc%5Etfw">August 24, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>After the original 16 weeks, those patients who demonstrated JIA&nbsp;American College of Rheumatology&nbsp;30 responses&nbsp;were given either&nbsp;tocilizumab or placebo for 24 weeks, with an open-label extension through to 2 years.&nbsp;&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Most <a href="https://twitter.com/hashtag/Actemra?src=hash&amp;ref_src=twsrc%5Etfw">#Actemra</a>-treated patients with polyarticular-course <a href="https://twitter.com/hashtag/juvenile?src=hash&amp;ref_src=twsrc%5Etfw">#juvenile</a> idiopathic <a href="https://twitter.com/hashtag/arthritis?src=hash&amp;ref_src=twsrc%5Etfw">#arthritis</a> increased in height <a href="https://t.co/7FysMCfsv9">https://t.co/7FysMCfsv9</a> <a href="https://t.co/9BBvaykLyH">pic.twitter.com/9BBvaykLyH</a>
&mdash; Healio Rheumatology (@HealioRheum) <a href="https://twitter.com/HealioRheum/status/1024031126665478145?ref_src=twsrc%5Etfw">July 30, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><a href="https://twitter.com/Dr___Mansour/status/1025397131400671232">https://twitter.com/Dr___Mansour/status/1025397131400671232</a>According to the results, the mean height&nbsp;SD score&nbsp;(SDS)&nbsp;increased from baseline to year 2 (+0.40, p &lt; 0.0001). In 74 of 103 patients (72%), height SDS was greater than at baseline, and mean height velocity was 6.7 &plusmn; 2.0 cm/year.&nbsp;&ldquo;Among patients with&nbsp;pcJIA&nbsp;at Tanner stage &le; 3 at baseline, 72% (74/103) had increased height SDS at the end of the study,&rdquo; the researchers concluded.&nbsp;&nbsp;Check out&nbsp;an article on&nbsp;the&nbsp;<a href="https://proddocwire.wpengine.com/docwire-pick/fda-guidance-osteoarthritis/">FDA&rsquo;s guidance for the treatment of osteoarthritis</a>.&nbsp;&nbsp;SOURCE:&nbsp;<a href="http://www.jrheum.org/content/early/2018/06/21/jrheum.170326">The Journal of Rheumatology</a>; <a href="https://www.healio.com/rheumatology/juvenile-arthritis/news/online/%7Bb234b950-3fb7-4bc7-991f-c15de5f11546%7D/most-actemra-treated-patients-with-polyarticular-course-jia-increased-in-height">Healio Rheumatology</a>&nbsp;

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Growth During Tocilizumab Therapy for Juvenile Idiopathic Arthritis

Rheumatology

In some cases, chronic inflammation (specifically juvenile idiopathic arthritis) can lead to some growth delays. In a study published in The Journal of Rheumatology, ...

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