Kerri Fitzgerald

DocwireNews

Jonathan U. Peled, MD, of Memorial Sloan Kettering Cancer Center discusses his study which looked at whether pre-HCT microbiota configuration may be an important determinant of post-transplantation outcomes. The study reported from a multicenter analysis conducted at four independent international institutions to test this hypothesis.The complications from a hematopoietic cell transplantation (HCT) is higher if a patient has lower diversity of microbes residing in the gut before beginning the transplantation process. While previous research has shown a similar relationship between outcomes and gut microbial composition shortly after transplantation, this study suggests that the association starts even before patients begin transplantation.Hematopoietic cell transplantation (HCT) is a procedure in which a patient receives blood-forming stem cells from a genetically similar donor. This approach is often used to treat aggressive blood cancers, but it can be associated with severe complications such as graft-versus-host disease (GVHD), a serious and potentially life-threatening complication that occurs when the donated immune cells attack the patient&rsquo;s cells as foreign tissue.Although this is an observational study and doesn&rsquo;t show cause and effect, the results suggest that it may be possible to reduce patients&rsquo; risk of complications by taking steps to improve the health of their gut microbiota before beginning HCT.

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Jonathan U. Peled, MD: Disruptions in the Gut Microbiota on Post-Transplantation Outcomes

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Jonathan U. Peled, MD, of Memorial Sloan Kettering Cancer Center discusses his study which looked at whether pre-HCT microbiota configuration may be an important determinant ...

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