Rebecca Araujo

DocwireNews

A study published in the <a href="https://www.nature.com/articles/s41416-020-01237-1">British Journal of Cancer</a> assessed whether esterase gene expression is of clinical significance in the treatment of multiple myeloma (MM).&ldquo;Several esterases have previously been reported to be dysregulated in specific cancers, with some also having the potential to be predictive or prognostic <a href="https://www.docwirenews.com/docwire-pick/significant-variability-in-myeloma-risk-factor-testing-across-the-u-s/" target="_blank" rel="noopener noreferrer">biomarkers</a>,&rdquo; wrote the study authors.This study enrolled a total of 134 patients with MM, including 56 with newly diagnosed and 78 with relapsed/refractory disease. Participants provided 171 bone marrow aspirates which underwent gene expression profiling. Genomic variations were validated against the Clinical Outcomes in MM to Personal Assessment of Genetic Profile (CoMMpass) dataset.The investigators reported strong variability between newly diagnosed and relapsed/refractory samples. The expression of the gene profiles UCHL5, SIAE, ESD, PAFAH1B3, PNPLA4, and PON1 were significantly altered upon progression from newly diagnosed to refractory disease.High expression of the OVCA2, PAFAH1B3, SIAE, and USP4 gene profiles were associated with significantly poorer prognosis compared with outcomes from patients with low expression (P&lt;0.05). Low PCED1B expression was also significantly associated with poor outcomes compared with samples with high expression (P&lt;0.05). Comparison with the CoMMpass dataset validated the finding that higher expression of PAFAH1B3 and SIAE, and lower expression of PCED1B, were associated with poor prognosis.In conclusion, the authors wrote, &ldquo;Further work is needed to elucidate the biological significance of esterases in cancer to better understand how they can be effectively utilized to activate anticancer drugs in tumor cells and their potential applicability as biomarkers of MM and its progression.&rdquo;<blockquote class="twitter-tweet">
A new article from <a href="https://twitter.com/HeckmanLab?ref_src=twsrc%5Etfw">@HeckmanLab</a> <a href="https://twitter.com/FIMM_UH?ref_src=twsrc%5Etfw">@FIMM_UH</a> and colleagues evaluating the biological signi&#64257;cance of esterase expression in multiple myeloma now available in <a href="https://twitter.com/BrJCancer?ref_src=twsrc%5Etfw">@BrJCancer</a>. Read it at: <a href="https://t.co/BvISXPCIbV">https://t.co/BvISXPCIbV</a>! <a href="https://twitter.com/hashtag/cancer?src=hash&amp;ref_src=twsrc%5Etfw">#cancer</a> <a href="https://twitter.com/hashtag/research?src=hash&amp;ref_src=twsrc%5Etfw">#research</a>
&mdash; Heckman Lab (@HeckmanLab) <a href="https://twitter.com/HeckmanLab/status/1357206951671791616?ref_src=twsrc%5Etfw">February 4, 2021</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><blockquote class="twitter-tweet">
New article: Prognostic significance of esterase gene expression in multiple myeloma. <a href="https://t.co/6MbSLJdBND">https://t.co/6MbSLJdBND</a> <a href="https://twitter.com/hashtag/MMSM?src=hash&amp;ref_src=twsrc%5Etfw">#MMSM</a> <a href="https://twitter.com/hashtag/MultipleMyeloma?src=hash&amp;ref_src=twsrc%5Etfw">#MultipleMyeloma</a> <a href="https://twitter.com/hashtag/hematology?src=hash&amp;ref_src=twsrc%5Etfw">#hematology</a> <a href="https://t.co/v6aioep3r5">pic.twitter.com/v6aioep3r5</a>
&mdash; Paperbirds_Hematology (@PaperbirdsM) <a href="https://twitter.com/PaperbirdsM/status/1357283174884118528?ref_src=twsrc%5Etfw">February 4, 2021</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>

Jayme Locke, MD, MPH

Joel M. Topf, MD, FACP

The Promise of Xenotransplantation

NKF Spring Clinical Meetings 2025

Leah Lawrence

Real-World Data Backs Invasive DFS as Surrogate Endpoint for OS in EBC

HR Breast Cancer

Sacituzimab Govitecan Showed Modest Activity for CNS Metastases

Triple-Negative Breast Cancer

Latest News

Is Esterase Gene Expression Linked to MM Prognosis?

Oncology

A study published in the British Journal of Cancer assessed whether esterase gene expression is of clinical significance in the treatment of multiple myeloma (MM). ...

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HER2 Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe