Charlotte Robinson

DocwireNews

CKD shares risk factors, pathogenic mechanisms, and genetic polymorphisms with age-related macular degeneration (AMD). It is also possible that CKD can increase susceptibility to AMD. However, previous research exploring an association between CKD and AMD has been inconclusive.&nbsp;&nbsp;Can Can Xue, PhD, and colleagues further investigated the matter in a cross-sectional study using datasets from the Asian Eye Epidemiology Consortium. They conducted a pooled analysis using individual-level participant data to study associations between CKD and eGFR with early and late AMD adjusted for sex, age, BMI, smoking status, hypertension, diabetes, total cholesterol, and study groups.&nbsp;&nbsp;The primary study outcome was odds ratio of early AMD and late AMD. The researchers defined AMD using the Wisconsin Age-Related Maculopathy Grading System, the International Age-Related Maculopathy Epidemiological Study Group classification, or the Beckman clinical classification. They defined CKD as eGFR &lt;60 mL/min/1.73 m&sup2;.&nbsp;&nbsp;Of the 51,253 study participants (mean age, 54.1&plusmn;14.5 years), 9.90% (5,079) had CKD, 9.00% had early AMD, and 0.71% had late AMD. Patients with CKD had higher odds of late AMD (OR, 1.46; 95% CI, 1.11-1.93; P=.008) after adjusting for confounders. Worse kidney function (per 10-unit eGFR decrease) was associated with late AMD (OR, 1.12; 95% CI, 1.05-1.19; P=.001), but CKD and eGFR did not demonstrate a significant association with early AMD (all P&ge;.149).&nbsp;The findings show that CKD and compromised kidney function are significantly associated with late AMD, emphasizing the importance of eye exams for patients with CKD.&nbsp;Source: <a href="https://doi.org/10.1016/j.ophtha.2023.12.030" target="_blank" rel="noopener">Ophthalmology</a>&nbsp;

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Is CKD Associated With Age-Related Macular Degeneration?

Chronic Kidney Disease

Previous research exploring an association between chronic kidney disease (CKD) and age-related macular degeneration (AMD) has been inconclusive.  

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