Victoria Socha

DocwireNews

Current guidelines recommend systolic blood pressure below 120 mm Hg in patients with chronic kidney disease. However, according to Chen Tang, PhD, and colleagues, the renoprotective effect of intensive blood-pressure lowering in patients with immunoglobulin A nephropathy (IgAN) is unclear. The researchers conducted a study at Peking University First Hospital in China, to examine the effect of intensive blood pressure control on the progression of IgAN.&nbsp;The study cohort included 1530 patients with IgAN. The researchers sought to define the relationship between baseline and time-updated blood pressure and composite kidney outcomes (development of end-stage renal disease or a 30% decline in eGFR). Multivariable causal hazard models and marginal structural models were used to model baseline and time-updated blood pressures.&nbsp;During a median follow-up of 43.5 months, 24.0% of study participants experienced the composite kidney outcomes. There were no significant associations observed between baseline blood pressure and the composite outcomes.&nbsp;Using marginal structural models with time-updated systolic blood pressure for analysis, there was a U-shaped association. Using systolic blood pressure 110-119 mm Hg as the reference, the HRs for the systolic blood pressure categories of &lt;110, 120-129, 130-139, and &ge;140 mm Hg were 1.48 (95% CI, 1.02-2.17), 1.13 (95% CI, 0.80-1.60), 2.21 (95% CI, 1.54-3.16), and 2.91 (95% CI, 1.94-4.35), respectively. The trend was more prominent in patients with proteinuria &ge;1g/day and eGFR &ge;60 mL/min/1.73 m2. There was no similar trend observed in analysis of time-updated diastolic blood pressure.&nbsp;In conclusion, the authors said, &ldquo;In patients with IgAN, intensive blood pressure control during the treatment period may retard the kidney disease progression, but the potential risk of hypertension still needs to be considered.&rdquo;&nbsp;Source: <a href="https://doi.org/10.1093/ndt/gfad139" target="_blank" rel="noopener">Nephrology Dialysis Transplantation</a>&nbsp;

Sara Nunnery, MD, MSCI

Reclassifying HER2: What Oncologists Need to Know About HER2-Low and -Ultralow Breast Cancer

HER2 Breast Cancer

Jeffrey Perl, MD

Joel M. Topf, MD, FACP

Thoughts From the 2025 Lazarus Award Winner

NKF Spring Clinical Meetings 2025

Brandon Twyford

DESTINY-Breast09 Demonstrates First-Line Superiority of Enhertu Plus Pertuzumab in HER2-Positive Metastatic Breast Cancer

Latest News

Intensive Blood Pressure Control in Patients With IgA Nephropathy

IgA Nephropathy

Researchers studied the effect of intensive blood pressure control on the progression of IgA nephropathy (IgAN). 

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HR Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe