Kaitlyn D’Onofrio

DocwireNews

The risk of&nbsp;hyperuricaemia&nbsp;(elevated serum urate concentration), a common gout risk factor, may come more from genes than diet, according to a recent study.&nbsp;A&nbsp;meta-analysis of five cohort studies, published in&nbsp;The&nbsp;BMJ, included&nbsp;16,760 people (8,414 men and 8,346 women) aged &gt; 18 who did not have kidney disease or gout and were not on urate-lowering or diuretic drugs. Serum urate measurements, dietary survey data, information on potential confounders,&nbsp;and genome wide genotypes&nbsp;were all recorded.&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
New research finds that diet is substantially less important than genes in the development of high blood urate levels, that often precede gout <a href="https://t.co/XMDvMnWgom">https://t.co/XMDvMnWgom</a> <a href="https://twitter.com/AucklandUni?ref_src=twsrc%5Etfw">@AucklandUni</a> <a href="https://twitter.com/otago?ref_src=twsrc%5Etfw">@otago</a> <a href="https://t.co/PB0LAjlZfb">pic.twitter.com/PB0LAjlZfb</a>
&mdash; The BMJ (@bmj_latest) <a href="https://twitter.com/bmj_latest/status/1052290611028664320?ref_src=twsrc%5Etfw">October 16, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>Researchers associated seven foods with elevated serum urate levels (beer, liquor, wine, potato, poultry, soft drink, and meat [beef, pork, or lamb]) and eight with decreased serum urate levels (eggs, peanuts, cold cereal, skim milk, cheese, brown bread, margarine, and non-citrus fruit). Beer and liquor were most strongly correlated with raised serum urate levels (1.38&nbsp;&mu;mol/L&nbsp;per week),&nbsp;equating to a 9.66&nbsp;&mu;mol/L (0.16 mg/dL) increase per daily serving.&nbsp;The total 63 food items the researchers studied&nbsp;explained 4.29% of variation in serum urate levels. In contrast,&nbsp;genetic risk score explained 7.9% of the varying serum urate levels.<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Studies analyze causes of <a href="https://twitter.com/hashtag/hyperuricemia?src=hash&amp;ref_src=twsrc%5Etfw">#hyperuricemia</a>, kidney effects of <a href="https://twitter.com/hashtag/gout?src=hash&amp;ref_src=twsrc%5Etfw">#gout</a> treatment with allopurinol. Learn more in the latest ACP Internist Weekly <a href="https://t.co/rqo8jZqBsP">https://t.co/rqo8jZqBsP</a>. <a href="https://t.co/PTI68X4U31">pic.twitter.com/PTI68X4U31</a>
&mdash; ACP (@ACPIMPhysicians) <a href="https://twitter.com/ACPIMPhysicians/status/1052229202924236803?ref_src=twsrc%5Etfw">October 16, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>&nbsp;&ldquo;Thus, in the datasets&nbsp;analysed&nbsp;here, overall diet explains much less variance in serum urate levels when compared with inherited genetic variants,&rdquo; the researchers wrote.&nbsp;One limitation of the present study is that the questionnaires were not identical in each of the studies the team analyzed. But the study still challenges the centuries-held belief that diet is a significant risk factor for gout development.&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Absolutely fascinating study (and picture too), on the role of diet in serum urate levels, by Major et al (2018) <a href="https://twitter.com/bmj_latest?ref_src=twsrc%5Etfw">@bmj_latest</a> <a href="https://twitter.com/hashtag/MedEd?src=hash&amp;ref_src=twsrc%5Etfw">#MedEd</a> <a href="https://twitter.com/hashtag/FOAMed?src=hash&amp;ref_src=twsrc%5Etfw">#FOAMed</a> <a href="https://twitter.com/hashtag/CardioEd?src=hash&amp;ref_src=twsrc%5Etfw">#CardioEd</a> <a href="https://t.co/OkqglPH6Cc">pic.twitter.com/OkqglPH6Cc</a>
&mdash; David Warriner (@DrDavidWarriner) <a href="https://twitter.com/DrDavidWarriner/status/1051094621193953281?ref_src=twsrc%5Etfw">October 13, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>&ldquo;Our results challenge widely held community perceptions that&nbsp;hyperuricaemia&nbsp;is primarily caused by diet, showing that genetic variants have a much greater contribution to&nbsp;hyperuricaemia&nbsp;in the general population than dietary exposure,&rdquo; the study authors concluded.&nbsp;<a href="https://proddocwire.wpengine.com/docwire-pick/rheumatology-picks/obesity-hypertension-linked-gout/">Study: Obesity, Hypertension, and Diuretic Use Linked to Gout</a>&nbsp;<a href="https://proddocwire.wpengine.com/abstracts/the-economic-burden-of-uncontrolled-gout-how-controlling-gout-reduces-cost/">The economic burden of uncontrolled gout: how controlling gout reduces cost</a>&nbsp;<a href="https://proddocwire.wpengine.com/abstracts/incidence-diabetes-mellitus-patients/">Decreased incidence of diabetes in patients with gout using benzbromarone</a>&nbsp;<a href="https://proddocwire.wpengine.com/docwire-pick/gout-medication-associated-kidney/">Gout Medication Not Associated with Kidney Function Decline</a>&nbsp;Source:&nbsp;<a href="https://www.bmj.com/content/363/bmj.k3951">The BMJ</a>

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Genetics May Contribute to Gout Risk More than Diet

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The risk of hyperuricaemia (elevated serum urate concentration), a common gout risk factor, may come more from genes than diet, according to a recent study.  ...

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