DocWire News Editors

DocwireNews

A study published in The Lancet reports &ldquo;evidence of the substantial impact&rdquo; of the HPV vaccine on reducing the incidence of HPV infections, high-grade cervical lesions, and anogenital warts.The researchers noted that it is too soon to tell whether the HPV vaccine will lead to decreased cervical cancer rates; however, the results suggest that this may be the case, as the study shows that <a href="https://www.docwirenews.com/docwire-pick/large-literature-review-observes-hpv-vaccine-protects-against-cervical-cancer/">HPV infections and lesions are on the decline</a>.This was a follow-up to a 2015 analysis published in The Lancet Infectious Diseases. In this updated systematic review and meta-analysis, researchers assessed MEDLINE and Embase for studies published between February 1, 2014, and October 11, 2018. Eligible studies compared the frequency of at least one HPV-related endpoint (genital HPV infections, anogenital wart diagnoses, or histologically confirmed cervical intraepithelial neoplasia grade 2+&nbsp;[CIN2+]) between pre- and post-vaccination periods among the general population and used the same population sources and recruitment methods before and after vaccination. Analyses were stratified by sex, age, and years since the introduction of the HPV vaccination.https://twitter.com/HoltgraveHealth/status/1144186766951366656The researchers included 65 articles in 14 high-income countries: 23 for HPV infection, 29 for anogenital warts, and 13 for CIN2+. The studies included 60 million people with up to eight years of follow-up data.<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Huge meta analysis! Vaccination programs substantially reduce HPV infections and precancerous cervical lesions <a href="https://t.co/Kwc62AficG">https://t.co/Kwc62AficG</a> <a href="https://t.co/EFRADRp9fk">https://t.co/EFRADRp9fk</a> (paywall) <a href="https://t.co/8Xmb63wmGg">https://t.co/8Xmb63wmGg</a> (paywall) <a href="https://twitter.com/hashtag/VaccinesSaveLives?src=hash&amp;ref_src=twsrc%5Etfw">#VaccinesSaveLives</a> <a href="https://twitter.com/hashtag/vaccines?src=hash&amp;ref_src=twsrc%5Etfw">#vaccines</a> <a href="https://twitter.com/hashtag/cancer?src=hash&amp;ref_src=twsrc%5Etfw">#cancer</a> <a href="https://twitter.com/hashtag/oncology?src=hash&amp;ref_src=twsrc%5Etfw">#oncology</a> <a href="https://twitter.com/hashtag/virus?src=hash&amp;ref_src=twsrc%5Etfw">#virus</a> <a href="https://twitter.com/hashtag/HPV?src=hash&amp;ref_src=twsrc%5Etfw">#HPV</a> <a href="https://t.co/VTxXZ1OsWY">pic.twitter.com/VTxXZ1OsWY</a>
&mdash; Nathan Letts, PhD &#127482;&#127462;&#127482;&#127462;&#127482;&#127462; (@Sciguy999) <a href="https://twitter.com/Sciguy999/status/1144174537178787840?ref_src=twsrc%5Etfw">June 27, 2019</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><h2>Infections are declining in women and men</h2>After five to eight years of vaccination, the prevalence of HPV 16 and 18 decreased significantly by 83% (relative risk [RR] = 0.17; 95% CI, 0.11-0.25) among girls aged 13 to 19 years and by 66% (RR=0.34; 95% CI, 0.23-0.49) among women aged 20 to 24 years. <a href="https://www.docwirenews.com/docwire-pick/hpv-vaccination-rates-remain-below-recommended-target-reducing-cancer-prevention-opportunities/">The prevalence of HPV</a> 31, 33, and 45 decreased significantly by 54% (RR=0.46; 95% CI, 0.33-0.66) among girls aged 13 to 19 years.Anogenital wart diagnoses decreased significantly by 67% (RR=0.33; 95% CI, 0.24-0.46) among girls aged 15 to 19 years, by 54% (RR=0.46; 95% CI, 0.36-0.60) among women aged 20 to 24 years, and by 31% (RR=0.69; 95% CI, 0.53-0.89) among women aged 25 to 29 years.<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Elimination of <a href="https://twitter.com/hashtag/cervicalcancer?src=hash&amp;ref_src=twsrc%5Etfw">#cervicalcancer</a> in rich countries may be possible within decades, thanks to the <a href="https://twitter.com/hashtag/HPVvaccine?src=hash&amp;ref_src=twsrc%5Etfw">#HPVvaccine</a>. Data from high-income countries shows <a href="https://twitter.com/hashtag/vaccination?src=hash&amp;ref_src=twsrc%5Etfw">#vaccination</a> led to an 83% reduction in <a href="https://twitter.com/hashtag/HPV?src=hash&amp;ref_src=twsrc%5Etfw">#HPV</a> infections in 15-to19-year-old girls over five to eight years. <a href="https://t.co/Ei6ukTspjZ">https://t.co/Ei6ukTspjZ</a>
&mdash; Dr Melvin Sanicas (@Vaccinologist) <a href="https://twitter.com/Vaccinologist/status/1144177818684809216?ref_src=twsrc%5Etfw">June 27, 2019</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>Anogenital wart diagnoses decreased significantly by 48% (RR=0.52; 95% CI, 0.37-0.75) among boys aged 15 to 19 years and by 32% (RR=0.68; 95% CI, 0.47-0.98) among men aged 20 to 24 years.After five to nine years of vaccination, CIN2+ decreased significantly by 51% (RR=0.49; 95% CI, 0.42-0.58) among screened girls aged 15 to 19 years and by 31% (RR=0.69; 95% CI, 0.57-0.84) among women aged 20 to 24 years.

Bradley Marder, MD

Joel M. Topf, MD, FACP

Gout Studies: Transplant Waitlisting and Bone Erosion

NKF Spring Clinical Meetings 2025

Jayme Locke, MD, MPH

The Promise of Xenotransplantation

Leah Lawrence

Real-World Data Backs Invasive DFS as Surrogate Endpoint for OS in EBC

HR Breast Cancer

Latest News

HPV Vaccine Is Having a “Substantial Impact,” May Decrease Rate of Cervical Cancer

Cervical Cancer

A study published in The Lancet reports “evidence of the substantial impact” of the HPV vaccine on reducing the incidence of HPV infections

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HER2 Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe