Kerri Fitzgerald

DocwireNews

Retina fluid is used to measure wet age-related macular degeneration (AMD) disease activity; however, limited evidence exists regarding early retinal fluid-free status and subsequent visual outcomes. A post-hoc analysis of pooled data from the HAWK and HARRIER trials suggests that patients who achieve early fluid-free status following anti-vascular endothelial growth factor treatment may have better visual outcomes than those with fluid present.&nbsp;The results of the study were published as part of the American Society of Retina Specialists 2020 Virtual Annual Meeting.Early fluid-free status was defined as the absence of intraretinal fluid (IRF) and subretinal fluid (SRF) at 12 weeks, independent of treatment. Treatment-na&iuml;ve patients (n=1,459) aged &ge;50 years with choroidal neovascularization lesions secondary to wet AMD with presence of subfoveal IRF and/or SRF and best-corrected visual acuity (BCVA) of 78&ndash;23 Early Treatment Diabetic Retinopathy Study (ETDRS) Letters were randomized to receive brolucizumab 6 mg or aflibercept 2 mg. Patients were grouped into two cohorts, in a treatment-agnostic manner, based on fluid status at week 12: fluid-free (IRF and SRF) and fluid present (IRF and/or SRF). Mean change in BCVA from baseline was evaluated at 12, 24, 48, and 96 weeks.At week 12, 1,075 patients (74%) were fluid-free and 384 (26%) had fluid present. At week 12, mean BCVA change from baseline was +6.4 ETDRS Letters for the fluid-free cohort and +4.9 for the fluid-present cohort; this trend continued for 96 weeks. After week 12, BCVA improvements from baseline in patients with early fluid-free status were also greater than that of fluid-present patients at the same time points: weeks 24 (+6.9 vs. +5.1), 48 (+7.4 vs. +5.8), and 96 (+6.5 vs. +4.7).&ldquo;The improvements occur as early as four weeks following the last loading dose (week 12) and continue to 96 weeks, demonstrating better long-term visual outcomes,&rdquo; the researchers concluded. &ldquo;The results of this current post-hoc analysis [add] to the understanding of anatomical and visual outcomes.&rdquo;Jhaveri CD, Wykoff CC, Khanani AM, et al. Early Fluid-Free Status &amp; Long-Term BCVA Outcomes with Anti-VEGF Treatment in nAMD: Post Hoc Analysis of Pooled Data From HAWK &amp; HARRIER Studies. Presented during the ASRS 2020 Virtual Annual Meeting, July 24-26, 2020.

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Fluid-Free Status Associated with Visual Outcomes in Patients with Wet AMD

ASRS 2020

Retina fluid is used to measure wet age-related macular degeneration (AMD) disease activity; however, limited evidence exists regarding early retinal fluid-free status and ...

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