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When it comes to&nbsp;rheumatoid arthritis (RA), cell-derived extracellular&nbsp;vesicles&nbsp;(EVs) are involved in&nbsp;its&nbsp;pathogenesis.&nbsp;These EVs&nbsp;play important roles in antigen presentation, inflammation, angiogenesis, cell&ndash;cell signal communication, thrombosis, and articular cartilage extracellular matrix degradation.&nbsp;By better understanding the&nbsp;pathogenic mechanism of RA, new therapies can be developed.&nbsp;In this review published in&nbsp;Molecular Immunology,&nbsp;researchers&nbsp;summarize&nbsp;recent advances in understanding the pathogenesis of RA, and how&nbsp;EVs could be&nbsp;used to develop new drug deliveries or&nbsp;targets for RA therapies.&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Role of extracellular vesicles in <a href="https://twitter.com/hashtag/rheumatoid?src=hash&amp;ref_src=twsrc%5Etfw">#rheumatoid</a> <a href="https://twitter.com/hashtag/arthritis?src=hash&amp;ref_src=twsrc%5Etfw">#arthritis</a> <a href="https://t.co/3j3w8G3sQp">https://t.co/3j3w8G3sQp</a> <a href="https://t.co/QNlFDZIg3A">pic.twitter.com/QNlFDZIg3A</a>
&mdash; Elsevier Immunology (@ImmunologyNews) <a href="https://twitter.com/ImmunologyNews/status/1018437537789079553?ref_src=twsrc%5Etfw">July 15, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
<a href="https://twitter.com/LisaAyers12345?ref_src=twsrc%5Etfw">@LisaAyers12345</a> Not read the article but saw this tweet and thought up your street <a href="https://t.co/lkpJZCEkGe">https://t.co/lkpJZCEkGe</a>
&mdash; Liz Ralph (@immsci) <a href="https://twitter.com/immsci/status/1003241350404427776?ref_src=twsrc%5Etfw">June 3, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>RA is a&nbsp;chronic, inflammatory, and systemic autoimmune disease. Symptoms include joint pain, swelling, deformity, and even disability.&nbsp;Although&nbsp;a&nbsp;number of&nbsp;pharmacologic intervention drugs for RA have been developed&nbsp;(including non-steroidal anti-inflammatory drugs, corticosteroids, and disease-modifying anti-rheumatic drugs), these therapies do not cure RA and can often have significant side effects.&nbsp;New biologics have made&nbsp;therapeutic improvements in RA treatment,&nbsp;but almost half of patients with RA&nbsp;do not respond to anti-TNF-&alpha; therapy.&nbsp;According to the review, &ldquo;gene therapy for RA treatment shows promise; however, it is unknown whether gene therapy is safe for treating patients with RA.&rdquo;&nbsp;Recent studies on EVs have shown positive&nbsp;pathogenic effects and therapeutic treatments of RA.&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
I expect you have seen this but just in case <a href="https://twitter.com/insarahsmind?ref_src=twsrc%5Etfw">@insarahsmind</a> enjoy <a href="https://t.co/zJRT9JKu5K">https://t.co/zJRT9JKu5K</a>
&mdash; Dr Angela Priestman (@angelapriestman) <a href="https://twitter.com/angelapriestman/status/1018453362105356294?ref_src=twsrc%5Etfw">July 15, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>SOURCE:&nbsp;<a href="https://www.sciencedirect.com/science/article/pii/S0161589017305795?via%3Dihub&amp;utm_campaign=MCRED_LSS_TW_Immunology&amp;sf190829074=1">Molecular Immunology&nbsp;</a>

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