Cailin Conner

DocwireNews

&ldquo;Surgery increases the risk of gout flare; however, the endovascular interventional procedures associated with this risk are not well understood,&rdquo; investigators of a study published in <a href="https://link.springer.com/article/10.1007/s40744-023-00617-2" target="_blank" rel="noopener">Rheumatology and Therapy</a> wrote. Therefore, the team of investigators conducted a retrospective study to investigate the clinical features and risk factors for gout flares that develop during the postsurgical period, including endovascular procedures.The researchers enrolled 222 patients with a history of gout who experienced postsurgical gout flares and 196 controls with gout histories but no flares within 20 days postsurgery. Comparative analysis was conducted to discern the clinical characteristics distinguishing patients who developed postsurgical gout flares from those who did not.The study revealed a significantly higher rate of endovascular interventional procedures (38.74% vs 13.48%; P&lt;.001) in the flare group compared with the no-flare group. Conversely, orthopedic surgeries exhibited a lower rate in the flare group (13.96% vs 41.84%; P&lt;.001).The Cox model analysis indicated that endovascular interventional procedures (hazard ratio [HR], 1.752; 95% CI, 1.126-2.724, P&thinsp;=0.013), and presurgical uric acid levels of&thinsp;&ge;7 mg/dL (HR, 1.489; 95% CI, 1.081-2.051; P=.015) were significantly associated with increased risks of postsurgical gout flare.Additionally, taking colchicine before surgery was significantly associated with a decreased risk of postsurgical gout flare (HR, 0.264; 95% CI, 0.090-0.774; P=.015). The types of endovascular interventional procedures, however, did not show a significant difference between the flare and no-flare groups.Ensuring effective management of presurgical serum uric acid levels and administering prophylactic colchicine treatment, according to the investigators, can effectively reduce the occurrence of gout flares in the postoperative period.

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Endovascular Procedures and Uric Acid Levels ≥7 mg/dL Increase Risk of Postoperative Gout Flares

Gout

A study revealed that endovascular interventional procedures significantly increase the risk of gout flares in the postsurgical period.

Endovascular Procedures and Uric Acid Levels ≥7 mg/dL Increase Risk of Postoperative Gout Flares 

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