Charlotte Robinson

DocwireNews

Hyperuricemia, a significant risk factor for gout, is associated with cardiovascular disease and its comorbidities. Elevated serum uric acid (SUA) levels also have potential effects on kidney transplant outcomes.Hyperuricemia is associated with graft failure and death among kidney transplant recipients (KTRs). Living kidney donor KTRs with heightened SUA levels are at higher risk for return to dialysis, retransplantation, and death from graft failure. However, some studies have suggested that SUA levels are not an accurate predictor of allograft function.Kian Djamali and colleagues hypothesized that higher SUA levels are associated with negative outcomes after kidney transplantation, including cardiovascular events (CVEs). In a study published in Kidney360, they assessed the potential association between SUA levels and CVEs following kidney transplantation and other composite outcomes.Using data from the Wisconsin Allograft Recipient Database, they evaluated all adult KTRs from January 1, 2000 to December 31, 2019. Kidney-only transplant recipients who maintained a functioning allograft without CVEs before the earliest SUA level measurement 5 to 13 months after transplant were eligible for the study.A total of 3,808 patients were followed for a median of 7.5 after their transplants. Of those, 81% were White, 40% were female, and the mean (SD) age was 51 (13) years. The researchers analyzed survival regarding CVEs, CVE-related mortality, death-censored graft failure, and uncensored graft failure within 10 years after transplantation.Transplant recipients with elevated SUA levels early after transplant had worse outcomes. Those with SUA levels greater than 6.8 mg/dl after transplant had a significantly higher risk for congestive heart failure (CHF) than those with SUA levels less than 6 mg/dl (adjusted hazard ratio [aHR], 1.55; 95% CI, 1.10-2.19; P=0.01), uncensored graft failure (aHR, 1.18; 95% CI, 1.02-1.36; P=0.03), and death-censored graft failure (aHR, 1.28; 95% CI, 1.01-1.61; P=0.04), after adjustment for variables including kidney graft function.However, no statistically significant association between SUA levels and other CVEs was observed, and there was no statistically significant risk for other outcomes of interest when comparing SUA levels less than 6 mg/dl with SUA levels of 6 to 6.8 mg/dl. The researchers acknowledged that the overall relationship between SUA levels and cardiovascular disease still appears to be inconclusive.Nonetheless, the findings suggest that SUA levels are associated with CHF, uncensored graft failure, and death-censored graft failure, and may be a predictor of poor outcomes among KTRs.&ldquo;While more robust studies are needed to identify SUA targets for KTRs, our data suggest that achieving a SUA level of 6.8 mg/dl or less may reduce the risk of uncensored graft failure, DCGF [death-censored graft failure], and CHF,&rdquo; the authors noted.Source: <a href="https://doi.org/10.34067/KID.0000000612" target="_blank" rel="noopener">Kidney360</a>

Jordana Jampel

Modernization and the Rising Burden of IBD: New Insights From a Global Study

Gastroenterology

FDA Approves Novel Blood Test for Alzheimer’s Detection

Dementia

Andrew Moreno

Is Plasma Mannose-Binding Lectin a Clue to Higher VTE Risk?

Latest News

Elevated Serum Uric Acid Associated With Negative Outcomes After Transplant

Gout

Researchers assessed the potential association between serum uric acid levels and cardiovascular events after kidney transplantation.

Elevated Serum Uric Acid Associated With Negative Outcomes After Transplant 

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HER2 Breast Cancer

HR Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe