Victoria Socha

DocwireNews

Results of previous studies have suggested sex-related disparities in the prognosis of chronic kidney disease (CKD). Akihiko Koshino, MD, and colleagues in <a href="https://web.hosp.kanazawa-u.ac.jp/">Japan</a> conducted a multicenter retrospective study to examine the influence of gender on the prognosis of immunoglobulin A nephropathy (IgA nephropathy). The researchers reported results of the study during a poster session at Kidney Week 2019 in a poster titled Sex-Related Disparities in IgA Nephropathy Progression.Patients were divided into two groups according to sex. Clinical data at renal biopsy and data on renal outcomes were collected during follow-up. Renal outcomes were defined as 30% decline in <a href="https://www.docwirenews.com/docwire-pick/immunosuppressive-therapy-in-patients-with-iga-nephropathy/">estimated glomerular filtration rate</a> (eGFR) from baseline. Cox regression models were used to evaluate the prognostic effects of gender.The study enrolled 238 patients with IgA nephropathy (male, 124; female, 114). Body mass index (BMI) and high-density lipoprotein (HDL) cholesterol were higher in men than women. Other characteristics, including age, blood pressure, eGFR, and proteinuria were similar between the two groups. Median follow-up was 88 months.In survival analysis, the hazard ratio (HR) of a 30% decline in eGFR was higher in men than in women (HR, 1.8; 95% confidence interval [CI], 1.1&mdash;3.4; P=.003). Gender was also seen as a prognostic factor in multivariable Cox regression analyses with matched BMI and HDL cholesterol (HR, 1.4; 95% CI, 1.1-2.2; P=.02).Proteinuria and eGFR were common risk factors for 30% decline in eGFR in gender-based survival analysis. Hypertension in men and lower HDL cholesterol in women were gender-specific risk factors of 30% eGFR decline.Study results suggested &ldquo;sex-related disparities in progression of IgA nephropathy,&rdquo; the researchers said.Source: Koshino A, Wada T, Ogura H, et al. Sex-related disparities in IgA nephropathy progression. Abstract of a poster presented at the American Society of Nephrology Kidney Week 2019 (Abstract TH-PO1015), November 7, 2019, Washington, DC.

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Disparities in IgA Nephropathy Progression Based on Gender

Nephrology Times

Results of previous studies have suggested sex-related disparities in the prognosis of chronic kidney disease (CKD). Akihiko Koshino, MD, and colleagues in Japan conducted a ...

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